Indirect and non-medical economic burden, quality-of-life, and disabilities of the myelofibrosis disease in Spain.

Introduction: Myelofibrosis is a non-frequent chronic myeloproliferative Philadelphia-negative chromosome neoplasm. It is a heavy incapacitating orphan disease and associated with high morbidity and mortality. In this context, indirect and non-medical costs are expected to be high.

Effects of food-deprivation and refeeding on the regulation and sources of blood glucose appearance in European seabass (Dicentrarchus labrax L.).

Sources of blood glucose in European seabass (initial weight 218.0±43.0g; mean±S.

Transactivation of cytosolic alanine aminotransferase gene promoter by p300 and c-Myb.

Alanine aminotransferase (Alt) provides a molecular link between carbohydrate and amino acid metabolism. In the cell context, the predominant Alt isozyme is located in the cytosol. To gain insight into the transcriptional regulation of the cytosolic alt gene (calt), we cloned and characterized the calt promoter from gilthead sea bream (Sparus aurata).