Publications by authors named "Juan Delgado-SanMartin"
A 2-day meeting was held by members of the UK Quantitative Systems Pharmacology Network (
Article Synopsis
- Animal studies in cancer drug development rely on subjective calliper measurements to estimate tumour volume, which can lead to inaccuracies due to the irregular shape of tumours.
- This paper analyzes data from 2,500 measurements across multiple mouse strains and tumour models, assessing the impact of tumour morphology on volume estimation and developing a new method called BioVolumeTM for more accurate results.
- BioVolumeTM uses 3D scanning technology to quickly and objectively capture and process tumour images, which may enhance data accuracy and provide potential biomarkers for animal welfare.
Xenografts--as simplified animal models of cancer-differ substantially in vasculature and stromal architecture when compared to clinical tumours. This makes mathematical model-based predictions of clinical outcome challenging. Our objective is to further understand differences in tumour progression and physiology between animal models and the clinic.
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