Publications by authors named "Juan De La Revilla Negro"
Article Synopsis
- Irritable bowel syndrome (IBS) is a common digestive disorder that causes abdominal pain and bowel issues, and dietary changes, especially reducing FODMAPs, are essential for treatment.
- A study involving 56 IBS patients revealed two microbial subtypes: IBS-P (which responded better to a low FODMAP diet) and IBS-H, with IBS-P showing higher levels of short chain fatty acids (SCFAs) before diet modification.
- After four weeks on the low FODMAP diet, IBS-P patients had a significant decrease in SCFA levels and reported greater symptom improvement compared to IBS-H, suggesting that managing SCFAs through diet can enhance relief from IBS symptoms.
Background: Management strategies and clinical outcomes vary substantially in patients newly diagnosed with Crohn's disease. We evaluated the use of a putative prognostic biomarker to guide therapy by assessing outcomes in patients randomised to either top-down (ie, early combined immunosuppression with infliximab and immunomodulator) or accelerated step-up (conventional) treatment strategies.
Methods: PROFILE (PRedicting Outcomes For Crohn's disease using a moLecular biomarker) was a multicentre, open-label, biomarker-stratified, randomised controlled trial that enrolled adults with newly diagnosed active Crohn's disease (Harvey-Bradshaw Index ≥7, either elevated C-reactive protein or faecal calprotectin or both, and endoscopic evidence of active inflammation).
Article Synopsis
- - This study assessed the effectiveness of various biologic therapies for inflammatory bowel disease (IBD) using real-world data from a large UK patient cohort over a significant period.
- - Results showed that vedolizumab (VDZ) was more effective than anti-TNF agents for ulcerative colitis, particularly after previous treatments failed, and that infliximab (IFX) outperformed adalimumab (ADA) for Crohn's disease.
- - The findings suggest that switching to a non-anti-TNF biologic after failure of the first anti-TNF treatment yields better outcomes, challenging existing treatment guidelines.
Objective: Reducing FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) can be clinically beneficial in IBS but the mechanism is incompletely understood. We aimed to detect microbial signatures that might predict response to the low FODMAP diet and assess whether microbiota compositional and functional shifts could provide insights into its mode of action.
Design: We used metagenomics to determine high-resolution taxonomic and functional profiles of the stool microbiota from IBS cases and household controls (n=56 pairs) on their usual diet.
Background And Aims: Rapid viral response (RVR) during antiviral treatment for hepatitis C virus (HCV) predicts sustained viral response (SVR). Recently, vitamin D levels have been associated with SVR. As sunlight is the most important source of vitamin D and shows seasonal variation, we evaluated the effect of season on viral kinetics during peginterferon/ribavirin-based therapy for HCV.
View Article and Find Full Text PDFIntroduction: The prevalence of portal vein thrombosis (PVT) in patients that have undergone liver transplantation (LT) is 9.7% (SD 4.5).
View Article and Find Full Text PDFChronic complications of acute appendicitis managed in a conservative manner are not frequent. We present a case of acute lower gastrointestinal hemorrhage in a young patient with a previous acute appendicitis without surgical intervention. The colonoscopy detected an appendicular bleeding which was surgically treated.
View Article and Find Full Text PDFIntroduction And Objectives: prevalence of viral hepatitis (B and C) changes geographically. Our aim was to determinate the prevalence of hepatitis B (HBV) and hepatitis C virus (HCV) serological markers in healthy working population and to describe the epidemiological characteristics associated to its presence.
Methods: blood samples and epidemiological data of 5,017 healthy workers from Murcia and Madrid were recorded prospectively.