Publications by authors named "Juan Carlos Rodriguez-Duque"
Article Synopsis
- The study investigates the link between metabolic dysfunction-associated steatotic liver disease (MASLD) and immune-mediated inflammatory diseases (IMIDs), finding a higher prevalence of advanced liver disease in IMID patients compared to a matched control group.
- Utilizing a case-control design, the research analyzed liver biopsy data and RNA sequencing from patients to identify significant differences in gene expression related to liver disease between IMID and control groups.
- Results indicate that IMIDs not only increase the risk of advanced steatotic liver disease but also suggest a unique pathway for MASLD development in these patients, separate from traditional metabolic factors.
Article Synopsis
- This study investigates the relationship between alcohol consumption levels and the severity of steatotic liver disease (SLD) across two different populations (Spain and the US).
- The research defines distinct categories of SLD based on alcohol intake and metabolic factors, showing that higher alcohol consumption correlates with increased prevalence of significant fibrosis and fatty liver disease complications.
- Findings from both the derivation and validation cohorts confirm that moderate alcohol intake is associated with a higher risk of progression to severe liver issues, reinforcing the importance of understanding alcohol's role in liver health.
Peroral endoscopic myotomy (POEM) is a minimally invasive endoscopic technique for the treatment of achalasia and its use has been widely spread in recent years. The Triangle Tip-Jet (TTJ) (Olympus Triangle TipKnife-J, KD645L) has become very popular in this field and currently one of the most used knives for POEM procedures. It has the capability of knife dissection along with submucosal injection and its triangle tip shape is especially useful for pulling tissue during the myotomy phase.
View Article and Find Full Text PDFNon-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, and its incidence has been increasing in recent years because of the high prevalence of obesity and metabolic syndrome in the Western population. Alcohol-related liver disease (ArLD) is the most common cause of cirrhosis and constitutes the leading cause of cirrhosis-related deaths worldwide. Both NAFLD and ArLD constitute well-known causes of liver damage, with some similarities in their pathophysiology.
View Article and Find Full Text PDFNon-alcoholic fatty liver disease (NAFLD) is currently the most prevalent cause of chronic liver disease (CLD). Currently, the only therapeutic recommendation available is a lifestyle change. However, adherence to this approach is often difficult to guarantee.
View Article and Find Full Text PDFNAFLD and type 2 diabetes: A practical guide for the joint management.
Gastroenterol Hepatol
December 2023
Non-alcoholic fatty liver disease (NAFLD) is becoming a major cause of liver disease-related morbidity, as well as mortality. Importantly, NAFLD is considered a mediator of systemic diseases including cardiovascular disease. Its prevalence is expected to increase, mainly due to its close association with obesity and type 2 diabetes mellitus (T2D).
View Article and Find Full Text PDFBackground: Estimates of detectable antinuclear antibodies (ANA) prevalence vary widely, from 6% in healthy populations to 50-80% in patients with autoimmune disease. However, there is a lack of evidence about the overall prevalence in inflammatory bowel disease (IBD) and ANA seroconversion after the beginning of biological therapy.
Objectives: The aim of the study was to investigate the overall prevalence of ANA in IBD patients, their relationship with different treatments, clinical outcomes and the seroconversion rate of ANA in patients treated with biological therapy.
Background & Aims: There is conflicting evidence regarding the prevalence of and risk factors for metabolic-associated fatty liver disease (MAFLD) in patients with inflammatory bowel disease (IBD). We aimed to determine MAFLD prevalence and risk factors in IBD patients.
Methods: Cross-sectional, case-control study included all consecutive IBD patients treated at 2 different university hospitals.
Efficacy and safety of endoscopic sleeve gastroplasty versus laparoscopic sleeve gastrectomy in obese subjects with Non-Alcoholic SteatoHepatitis (NASH): study protocol for a randomized controlled trial (TESLA-NASH study).
Trials
October 2021
Background: Non-alcoholic steatohepatitis (NASH) is frequently associated with obesity, and its standard treatment is weight loss with diet and exercise; a dy% weight reduction has been associated with improvement in liver histological and analytical abnormalities. However, less than 25% of subjects achieve this goal. Laparoscopic sleeve gastrectomy (LSG) represents the most common procedure of bariatric surgery, providing effective weight loss and improvement in comorbidities such as NASH, but it is associated with several postoperative complications.
View Article and Find Full Text PDFBackground & Aims: Cardiovascular disease (CVD) is the main cause of mortality among non-alcoholic fatty liver disease (NAFLD) patients. The aim was to explore the level of knowledge and clinical management of cardiovascular risk (CVR) in NAFLD patients by Digestive Disease specialists.
Methods: An anonymous web-based survey was designed with 44 close-ended questions, divided into five sections, that were based on current guidelines on CVD prevention.