Publications by authors named "Juan Carlos Rodriguez-Aldama"
Immune Reconstitution Inflammatory Syndrome Related to Antiretroviral Therapy Initiation in People With HIV and Mpox: An Observational Retrospective Study.
Open Forum Infect Dis
October 2024
The study aims to compare the outcomes of initiating antiretroviral therapy early vs late in people with HIV and mpox. No worse outcomes were found associated with mpox-related immune reconstitution inflammatory syndrome among those who started antiretroviral treatment early, suggesting initiation as soon as possible.
View Article and Find Full Text PDFCoformulated Bictegravir/Emtricitabine/Tenofovir Alafenamide for Postexposure Prophylaxis After Sexual Assault: A Retrospective Real-World Study.
Open Forum Infect Dis
August 2024
We report the experience of bictegravir/emtricitabine/tenofovir alafenamide for nonoccupational postexposure prophylaxis in sexual assault cases. Between June 2021 and October 2023, 39 individuals completed the 28-day follow-up; 41% experienced some side effects, and 1 person discontinued the drug because of a rash. No individuals seroconverted to HIV during the follow-up period.
View Article and Find Full Text PDFBackground: The global shift in healthcare during the COVID-19 pandemic led to challenges in the care of people living with HIV.
Methods: We conducted a retrospective study that aimed to delineate sociodemographic, clinical characteristics and outcomes, of people living with HIV diagnosed with ocular syphilis.
Results: Fifty-three people living with HIV were identified with ocular syphilis.
Mpox-related ophthalmic disease has been reported as infrequent. We retrospectively describe the ocular manifestations present in 11 of 100 patients with confirmed mpox; 9 were people with HIV. We suggest that an ophthalmological evaluation should be performed in all patients with ocular symptoms or moderate and severe mpox disease.
View Article and Find Full Text PDFBackground: Since May, 2022, a large global outbreak of human mpox (formerly known as monkeypox) has predominantly affected men who have sex with men. The strain responsible, Clade IIb, has mutated substantially from precursors originating from the 2017-18 outbreak in Nigeria. Immunity to smallpox, another orthopoxvirus, via previous infection or vaccination provides lifelong immunity.
View Article and Find Full Text PDFArticle Synopsis
- A significant portion of the 2022 mpox outbreak involved individuals with HIV, particularly those with low CD4 cell counts, suggesting the need to understand their clinical outcomes.
- Data from a network of clinicians across 19 countries was analyzed, focusing on adults living with HIV and CD4 counts below 350 cells per mm to assess their presentation and complications from mpox.
- Out of 382 cases analyzed, most individuals were men, with a median age of 35, and those with CD4 counts under 100 cells per mm experienced more severe complications, highlighting the risks associated with advanced HIV.
COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes.
Viruses
September 2021
Article Synopsis
- * Conducted in Mexico City, the research analyzed data from 828 women who tested negative and 298 who tested positive for COVID-19, finding that only a small percentage of the positive group exhibited symptoms.
- * Key findings included a higher occurrence of placental fibrinoid in women with low C values and a significant association between preeclampsia and COVID-19 symptoms, particularly in those diagnosed early in their pregnancy.
Prevalence, clinical features, and outcomes of SARS-CoV-2 infection in pregnant women with or without mild/moderate symptoms: Results from universal screening in a tertiary care center in Mexico City, Mexico.
PLoS One
May 2021
Article Synopsis
- The study investigates the outcomes of pregnant women with and without SARS-CoV-2 infection during a peak transmission period in Mexico City, focusing on 240 cases.
- Findings reveal that 29% of pregnant women tested positive for COVID-19, with the majority being asymptomatic, and no maternal deaths were recorded despite a higher incidence of preeclampsia in infected women.
- Positive COVID-19 status in mothers was associated with more neonatal admissions to NICU and longer hospitalization, underscoring the need for COVID-19 screening during delivery in high-risk areas.
Substantial reduction of healthcare facility-onset Clostridioides difficile infection (HO-CDI) rates after conversion of a hospital for exclusive treatment of COVID-19 patients.
Am J Infect Control
July 2021
Healthcare facility-onset Clostridioides difficile infection rates substantially dropped in a Mexican hospital after its conversion to a full COVID-19 setting, despite heavy contamination of the environment the previous year. Better adherence to hand hygiene and contact precautions may help explain this finding.
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