Beneficial effects of immunotherapy with extracts derived from Actinomycetales on rats with spontaneous obesity and diabetes.

Aims: To determine whether immunotherapy with heat-killed, selected Actinomycetales species could influence the progression of spontaneous Type 2 diabetes mellitus and obesity in a rat model.

Materials & Methods: Preparations of either Gordonia bronchialis, Tsukamurella inchonensis or a saline placebo were given by three subcutaneous injections, 30 days apart, starting when rats were aged 120 days, just before development of Type 2 diabetes mellitus, and at day 440, when the disease was well established. Bodyweight, blood sugar, cholesterol, triglycerides and insulin levels were measured to determine the effects and at the end of the experiments, animals were subjected to necropsy.

[Dynamic modifications in islets of Langerhans in two lines of spontaneously diabetic rats].

The eSMT rat is derived from the crossing of eSS and beta, both lines belonging to the IIM strain, while eSS is a model of type 2 diabetes without overweight and beta develops moderate obesity and late glucose intolerance. Metabolic characteristics and histopathological findings in endocrine pancreas of eSS and eSMT were compared. Young eSMT animals are more robust than eSS and develop more intense fasting hyperglycemia and glucose intolerance at an earlier age.

[Feeding behavior and glycemic profile in two lines of rats with genetic diabetes].

Introduction: Food intake can aggravate diabetes in humans and in animal models. In rat model systems, the eSMT rat strain shows increased diabetes expression and higher biomass than its eSS parental line. OBVJECTIVE: The feeding behavior of eSMT and eSS males was compared under conditions of ad libitum versus restrictive food intake.

[Chronic bronchial dilatations in different colonies of laboratory rats].

Bronchiectasis occurred naturally in 12-month-old spontaneously diabetic eSS male rats. The lungs of 3 and 6-month-old eSS rats were compared in eumetabolic eSS rats from three inbred lines consisting of inbred spontaneously diabetic eSS derived from IIM strain; these were compared with eumetabolic, outbred Wistar rats, paired by sex and age. Acrylic casts of bronchial tree were obtained after injection of a plastic substance.