Publications by authors named "Juan Carlos Perez Razo"
Article Synopsis
- The study aimed to examine the expression of apelin (APLN) and its receptor (APLNR) in visceral adipose tissue (VAT) among individuals with class 3 obesity, with a focus on those with and without hypertension.
- A total of 75 participants were analyzed, showing that those with hypertension had higher levels of APLN but lower levels of APLNR compared to their non-hypertensive counterparts.
- Additionally, individuals with hypertension exhibited reduced phosphorylation of endothelial nitric oxide synthase (eNOS), suggesting a link between altered APLN/APLNR expression and eNOS activity in those with obesity and hypertension.
Epidemiological Profile and Social Welfare Index as Factors Associated with COVID-19 Hospitalization and Severity in Mexico City: A Retrospective Analysis.
Int J Environ Res Public Health
November 2022
Article Synopsis
- * The research analyzed data from 3,963 COVID-19 patients treated at a medical center in Mexico City from March to July 2020, focusing on demographics and SWI, which measures living conditions.
- * Findings reveal that lower SWI is linked to higher probabilities of hospitalization, need for mechanical ventilation, and increased mortality rates, highlighting the impact of socioeconomic factors on clinical outcomes in COVID-19 patients.
Article Synopsis
- Obesity is linked to a higher risk of hypertension, which leads to public health concerns, especially in class 3 obesity cases.
- A study was conducted on women with class 3 obesity to analyze RNA expression of adiponectin and leptin in their adipose tissue, comparing those with and without hypertension.
- Results showed that women with higher blood pressure had significantly increased adiponectin mRNA levels in subcutaneous adipose tissue, highlighting a potential relationship between adipokines and hypertension treatment.
Objective: The present study aimed to identify Mollicutes infection in the reproductive system. We also examined the microbiological, biochemical, and antimicrobial profiles of Mollicutes infection, which are potentially associated with clinical reproductive abnormalities causing infertility in couples.
Methods: Thirty-seven couples who were attending an infertility clinic were enrolled.
: The aim of this study was to investigate if serum concentrations of apelin-36, apelin-17, apelin-13 or apelin-12 were different in obesity class 3 individuals with hypertension, when compared to those without hypertension (normal or high-normal).: Twenty six individuals with obesity class 3-related hypertension and thirty three individuals without hypertension, who were divided in individuals with normal (n = 23) or with high-normal (n = 10) blood pressure (BP) were analyzed. All individuals presented obesity class 3, without diabetes mellitus.
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- The study aimed to assess the role of polymorphisms in APLN and APLNR genes as potential markers for hypertension in Mexican-Mestizo patients through a case-control approach involving 400 normotensive and 383 hypertensive subjects.
- The findings revealed that specific polymorphisms of the APLNR gene (rs7119375 and rs10501367) significantly decreased the risk of essential hypertension when adjusted for various health factors, while APLN gene polymorphisms showed no significant association.
- Additionally, haplotype analysis indicated that the H1 haplotype increased the risk of essential hypertension, whereas the H2 haplotype decreased it, suggesting the need for further research in this area.
Background: Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) have been associated with diastolic blood pressure, hypertension, and other cardiovascular diseases; however, results of these studies are still controversial. In this study, we sought to determine whether 2 functional variants (rs1801133 and rs13306560) within the MTHFR are associated with hypertension in Mexican-Mestizos.
Methods And Results: We performed a case-control study with 1214 subjects including adults and children to test for the association of both single nucleotide polymorphisms with essential hypertension.