Publications by authors named "Juan Carlos Cotrina-Aliaga"
Retraction notice to "The protective role of sulforaphane and Homer1a in retinal ischemia-reperfusion injury: Unraveling the neuroprotective interplay" [Life Sci. 329 (2023) 121968].
Life Sci
May 2024
Aims: Pain is a profoundly debilitating symptom in cancer patients, leading to disability, immobility, and a marked decline in their quality of life. This study aimed to investigate the potential roles of miR-199a-3p in a murine model of bone cancer pain induced by tumor cell implantation in the medullary cavity of the femur.
Materials And Methods: We assessed pain-related behaviors, including the paw withdrawal mechanical threshold (PWMT) and the number of spontaneous flinches (NSF).
Article Synopsis
- - T helper (Th) 17 cells are crucial in combating infections and are involved in autoimmune diseases and chronic inflammation.
- - Long non-coding RNAs (lncRNAs) play significant roles in regulating gene expression and are linked to various biological processes important for immune cell function.
- - The article explores recent research on how lncRNAs influence Th17 cell differentiation across several health issues, including autoimmune diseases, cancer, asthma, heart disease, and infections.
Aims: Retinal ischemia/reperfusion (I/R) injury is a common pathological basis for various ophthalmic diseases. This study aimed to investigate the potential of sulforaphane (SFN) and Homer1a in regulating cell apoptosis induced by retinal I/R injury and to explore the underlying regulatory mechanism between them.
Materials And Methods: In in vivo experiments, C57BL/6J mice and Homer1/Homer1a/Nestin-Cre mice were used to construct retinal I/R injury models.
Article Synopsis
- * It highlights the effectiveness of bioresponsive nanocarriers that can deliver drugs and genes directly to PC cells, enhancing drug accumulation and promoting tumor suppression while minimizing side effects on normal cells.
- * Additionally, it introduces phototherapy as a new cancer treatment method that works alongside traditional therapies, utilizing nanoparticles to trigger cell death and improve targeting for better outcomes in managing pancreatic cancer.
The effects of methotrexate on the immune responses to the COVID-19 vaccines in the patients with immune-mediated inflammatory disease: A systematic review of clinical evidence.
Transpl Immunol
August 2023
COVID-19 vaccines exhibit high levels of immunogenicity in the overall population. Data on the effects of immunomodulators on the consequences of COVID-19 in patients with Immune-mediated inflammatory diseases (IMIDs) remains scarce. This systematic review aimed to evaluate the immune responses to the COVID-19 vaccines in IMID patients receiving methotrexate (MTX) compared to healthy individuals.
View Article and Find Full Text PDFExosomes are now significant players in both healthy and unhealthy cell-to-cell communication. Exosomes can mediate immune activation or immunosuppression, which can influence the growth of tumors. Exosomes affect the immune responses to malignancies in various ways by interacting with tumor cells and the environment around them.
View Article and Find Full Text PDFBackground And Objectives: Brain Tumor Fusion-based Segments and Classification-Non-enhancing tumor (BTFSC-Net) is a hybrid system for classifying brain tumors that combine medical image fusion, segmentation, feature extraction, and classification procedures.
Materials And Methods: to reduce noise from medical images, the hybrid probabilistic wiener filter (HPWF) is first applied as a preprocessing step. Then, to combine robust edge analysis (REA) properties in magnetic resonance imaging (MRI) and computed tomography (CT) medical images, a fusion network based on deep learning convolutional neural networks (DLCNN) is developed.