Publications by authors named "Juan Carlos Castillo-Farfan"

Since the inception of in vitro fertilization (IVF), monitoring of controlled ovarian stimulation (COS) has traditionally involved numerous appointments for ultrasound and laboratory testing to guide medication use and dosing, determine trigger timing, and allow for measures to reduce the risk of ovarian hyperstimulation syndrome (OHSS). Recent advances in the field of assisted reproductive technology (ART) have called into question the timing and frequency of COS monitoring appointments, as discussed in this commentary.

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Introduction: Embryo implantation is a complex and poorly understood process. Most studies to date have focused on the analysis of the endometrium at the end of the estrogenic phase, while the available data on its importance after secretory transformation are limited and inconsistent. Current evidence does not allow for a conclusive interpretation of the changes observed in the pre-implantation endometrium, whether in the natural or replacement cycle, and their relevance in the development of a pregnancy or the implications for clinical practice.

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Article Synopsis
  • The study compared two protocols for ovarian stimulation in oocyte donors to evaluate the quantity of cumulus-oocyte complexes and mature oocytes (metaphase II).
  • The TAIL group received a single injection of corifollitropin alfa after a 7-day contraceptive break, while the control group followed a conventional protocol with additional rFSH from the 8th day.
  • Results showed that the TAIL group had significantly fewer cumulus-oocyte complexes and metaphase II oocytes, as well as a higher rate of failed oocyte retrieval compared to the control group.
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