Publications by authors named "Juan Canton"
Article Synopsis
- * Dasatinib, a medication used for chronic myeloid leukemia, shows promise against HIV-1 by preserving the antiviral activity of the SAMHD1 protein in CD4+ T cells and reducing the phosphorylation that inactivates it, inhibiting HIV-1 infection in macrophages.
- * Short-term dasatinib treatment lowers inflammatory cytokines in macrophages while maintaining some antiviral responses, suggesting that combining dasatinib with ART could effectively target HIV-1 reservoirs and reduce inflammation in people living with HIV.
Introduction: HIV-1 infection may produce a detrimental effect on the immune response. Early start of antiretroviral therapy (ART) is recommended to preserve the integrity of the immune system. In fact, people with HIV (PWH) and normal CD4/CD8 ratio appear not to be more susceptible to severe forms of COVID-19 than the general population and they usually present a good seroconversion rate in response to vaccination against SARS-CoV-2.
View Article and Find Full Text PDFBackground: The aetiological relationship between human papillomavirus (HPV) infection and cervical cancer (CC) is widely accepted. Our goal was to determine the prevalence of HPV types in Mexican women attending at the Mexican Institute for Social Security from different areas of Mexico.
Materials And Methods: DNAs from 2,956 cervical samples were subjected to HPV genotyping: 1,020 samples with normal cytology, 931 with low-grade squamous intraepithelial lesions (LGSIL), 481 with high grade HGSIL and 524 CC.