NIK controls classical and alternative NF-κB activation and is necessary for the survival of human T-cell lymphoma cells.

Purpose: Peripheral T-cell lymphomas (PTCL) are a heterogeneous entity of neoplasms with poor prognosis, a lack of effective therapies, and a largely unknown molecular pathology. Deregulated NF-κB activity has been associated with several lymphoproliferative diseases, but its importance in T-cell lymphomagenesis is poorly understood. We investigated the function of the NF-κB-inducing kinase (NIK), in this pathway and its role as a potential molecular target in T-cell lymphomas.

[Giant retroperitoneal cystic lymphangioma in adults].

Objectives: To report one case of retroperitoneal cystic lymphangioma in an adult patient.

Methods: We describe the case of a 70 year-old female patient who complained of periumbilical pain and progressive increases of abdominal perimeter over a few months. Physical examination showed a great abdominal mass; CT scan confirmed its cystic nature.