Publications by authors named "Juan C Silla"
Article Synopsis
- The study investigates how HIV infection alters DNA methylation patterns and how antiretroviral therapy (ART) impacts these changes over 96 weeks in individuals with HIV compared to uninfected controls.
- Researchers found 430 differentially methylated positions (DMPs) in HIV-positive patients before ART, with ART restoring nearly half of these modifications and affecting 845 CpG positions.
- The analysis revealed that while ART helps restore some DNA methylation changes, it shows a weak correlation with improvements in immune markers like CD4 cell counts and the CD4/CD8 ratio in HIV patients.
Background: Clinical practice guidelines recommend assessment of subclinical atherosclerosis using imaging techniques in individuals with intermediate atherosclerotic cardiovascular risk according to standard risk prediction tools.
Objectives: The purpose of this study was to develop a machine-learning model based on routine, quantitative, and easily measured variables to predict the presence and extent of subclinical atherosclerosis (SA) in young, asymptomatic individuals. The risk of having SA estimated by this model could be used to refine risk estimation and optimize the use of imaging for risk assessment.
Overgrowth syndromes (OGS) are a group of disorders in which all parameters of growth and physical development are above the mean for age and sex. We evaluated a series of 270 families from the Spanish Overgrowth Syndrome Registry with no known OGS. We identified one de novo deletion and three missense mutations in RNF125 in six patients from four families with overgrowth, macrocephaly, intellectual disability, mild hydrocephaly, hypoglycemia, and inflammatory diseases resembling Sjögren syndrome.
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