Angiotensin-converting enzyme insertion/deletion gene polymorphism and progression of Chagas' cardiomyopathy.

Chagas' disease is common in Latin America and is caused by Trypanosoma cruzi. It is usually associated with chronic cardiomyopathy, the progression of which could be related to genetic factors. As alterations in the renin-angiotensin-aldosterone system have been reported in the disease, the aim of this study was to determine whether associated genetic polymorphisms influence the development of myocardial damage.