Long-term impact of an educational antimicrobial stewardship programme in primary care on infections caused by extended-spectrum β-lactamase-producing Escherichia coli in the community: an interrupted time-series analysis.

Background: There is little evidence on the ecological effect and sustainability of antimicrobial stewardship programmes (ASPs) in primary-care settings. We aimed to determine whether a multimodal, educational ASP would be sustainable in the long-term and reduce the incidence of infections caused by extended-spectrum β-lactamase-producing Escherichia coli in the community by optimising antibiotic use.

Methods: We did this quasi-experimental intervention study in 214 primary health centres of four primary health-care districts in Andalusia, Spain.

[A review of the medication in polymedicated elderly with vascular risk: a randomised controlled trial].

Objective: To analyse the effectiveness of a medication review based on intervention directed at improving the appropriateness of drug treatments according to the established guidelines, as well as blood pressure, serum lipid and blood glucose control in elderly patients on multiple medication, and cardiovascular disease or high risk of cardiovascular disease.

Design: A randomised controlled trial with blind evaluation.

Setting: Fourteen Primary Health Care centres in Andalusia

Participants: A total of 323 patients older than 65 on polypharmacy and cardiovascular disease or high risk of cardiovascular disease.

[The use and suitability of absorbent products for urinary incontinence in a primary health care district].

Objective: To calculate the use of absorbent products in patients with urinary incontinence in the Seville District Primary Health Care, and to compare the use over time, and to calculate the health costs and their variation during the period 2005-2009.

Method: A cross-sectional and descriptive observational study was conducted on the use of urinary incontinence absorbents in the Seville District Primary Health Care, from 2005 and 2009. Patients registered as using urinary incontinence absorbents (UIA) during that period were included as the study population.

[Prevalence of multiple medication and cardiovascular risk in patients over 65 years].

Objective: To describe the prevalence of multiple medication in patients over 65 years.

Design: Cross-sectional study.

Setting: Sevilla and Jerez-Costa North-West Primary Health Care Districts.

[Trends in preventive drug prescription in the Primary Care District of Seville [2000-2003]].

Objectives: To describe trends in prescription rates for biphosphonates, raloxifene, calcitonin, statins and hormone replacement therapy (HRT) between 2000 and 2003 and to assess the impact of mass media information on the interruption of the Women's Health Initiative trial on HRT prescription rates.

Methodology: We performed a descriptive, ecological study, with time (month) as the observation unit. Monthly rates of bisphosphonate, calcitonin, raloxifene, statins and HRT prescription, in defined daily doses per 1000 persons, were measured in the population assigned to 249 family physicians in 27 health centers in Seville.