Publications by authors named "Juan Antonio Cordero Varela"
Adequate nutrient supply is crucial for the proper development of the embryo. Although nutrient supply is determined by maternal diet, the gut microbiota also influences nutrient availability. While currently there is no cure for neural tube defects (NTDs), their prevention is largely amenable to maternal folic acid and inositol supplementation.
View Article and Find Full Text PDFNeuroblastoma is a neural crest cell-derived pediatric tumor characterized by high inter- and intra-tumor heterogeneity, and by a poor outcome in advanced stages. Patient-derived xenografts (PDXs) have been shown to be useful models for preserving and expanding original patient biopsies in vivo, and for studying neuroblastoma biology in a more physiological setting. The maintenance of genetic, histologic, and phenotypic characteristics of the original biopsy along serial PDX passages in mice is a major concern regarding this model.
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- This study evaluated how the introduction of the pneumococcal conjugate vaccine 13 (PCV13) affected the occurrence and types of invasive pneumococcal disease (IPD) in children in Andalusia between 2018 and 2020.
- The incidence of IPD initially rose slightly from 2018 to 2019 but then significantly decreased in 2020, with the cases attributed to PCV13 serotypes dropping from 28% compared to earlier years (2006-2009).
- Non-PCV13 serotypes such as 24F and 11A emerged as common strains during the study period, raising concerns about their potential for invasiveness and antibiotic resistance, indicating a need for ongoing
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- Predictive biomarkers for trabectedin in advanced soft-tissue sarcomas (STS) remain an unmet need, with previous studies focusing on a limited number of DNA damage repair (DDR) genes.
- Through a retrospective study, a new six-gene predictive signature for trabectedin efficacy was developed by analyzing 118 DDR-related genes in 139 tumor samples, revealing significant differences in progression-free survival between high-risk and low-risk groups.
- The study identified potential new biomarkers for sensitivity (PARP3, CCNH) and resistance (DNAJB11, PARP1) to trabectedin, suggesting that targeting these genes could improve treatment outcomes.
The Roles of Imprinted and Gene Overexpression Caused by Promoter CpG Island Hypomethylation as Diagnostic and Prognostic Biomarkers for Non-Small Cell Lung Cancer Patients.
Cancers (Basel)
July 2020
Genomic imprinting is a process that involves one gene copy turned-off in a parent-of-origin-dependent manner. The regulation of imprinted genes is broadly dependent on promoter methylation marks, which are frequently associated with both oncogenes and tumor suppressors. The purpose of this study was to assess the DNA methylation patterns of the imprinted solute-carrier family 22 member 18 ( and antisense genes in non-small cell lung cancer (NSCLC) patients to study their relevance to the disease.
View Article and Find Full Text PDFUnderstanding how genetic variation contributes to phenotypic differences is a fundamental question in biology. Combining high-throughput gene function assays with mechanistic models of the impact of genetic variants is a promising alternative to genome-wide association studies. Here we have assembled a large panel of 696 strains, which we have genotyped and measured their phenotypic profile across 214 growth conditions.
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