Publications by authors named "Ju-ren Zhu"
[Pathogenesis of liver fibrosis in patients with chronic hepatitis B].
Zhonghua Gan Zang Bing Za Zhi
June 2009
Objective: To explore the role of sinusoidal endothelial cell in the development of liver fibrosis, and to dissect the relationship among hepatic microcirculation disorders, hepatic sinusoidal capilarization and liver fibrosis.
Methods: Liver biopsy was performed in fifty-six patients with chronic hepatitis B. The liver tissues were observed under light microscope and transmitted electronic microscope.
Effects of endogenous nitric oxide induced by 5-fluorouracil and L-Arg on liver carcinoma in nude mice.
World J Gastroenterol
December 2007
Article Synopsis
- - The study investigates how nitric oxide produced endogenously by the combination of 5-fluorouracil (5-FU) and L-arginine (L-Arg) affects liver cancer growth in a nude mouse model injected with human liver carcinoma cells (BEL-7402).
- - Results show that the combination of 5-FU and L-Arg significantly reduces tumor size compared to control and 5-FU alone, with a marked increase in cell death (apoptosis) and tumor necrosis observed.
- - The study also finds that the levels of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) in tumor tissue increase with treatment, suggesting a correlation between nitric oxide
Objectives: To explore the effects of sodium phenylbutyrate on the proliferation, differentiation, cell cycle arrest and induction of the P(21WAF1/CIP1) anti-oncogene in human liver carcinoma cell lines Bel-7402 and HepG2.
Methods: Bel-7402 and HepG2 human liver carcinoma cells were treated with sodium phenylbutyrate at different concentrations. Light microscopy was used to observe morphological changes in the carcinoma cells.
Background & Objective: Accumulating evidences showed that the overexpression of multidrug resistance-associated protein 2 (MRP2) was the main cause of multidrug resistance in hepatocellular carcinoma (HCC); and the methylated cytosine at cytosine-guanine (CpG) dinucleotides might silence the gene expression. This study was to evaluate the inhibiting effect of methylated oligonucleotide (MON) on MRP2 gene transcription.
Methods: MON complementary to human MRP2 promoter region was designed.
[The expression of liver tissue renin-angiotensin system mRNA in patients with chronic hepatitis and liver cirrhosis].
Zhonghua Gan Zang Bing Za Zhi
February 2004
Long-term effect of stent placement in 115 patients with Budd-Chiari syndrome.
World J Gastroenterol
November 2003
Aim: To report the long-term effect of stent placement in 115 patients with Budd-Chiari syndrome (BCS).
Methods: One hundred and fifteen patients with BCS were treated by percutaneous stent placement. One hundred and two patients had IVC stent placement, 30 patients had HV stent placement, 17 of them underwent both IVC stent and HV stent.
[Effects of interferon-alpha on the apoptosis and gene expression of hepatic stellate cells].
Zhonghua Gan Zang Bing Za Zhi
October 2003
Effects of heparin on liver fibrosis in patients with chronic hepatitis B.
World J Gastroenterol
July 2003
Aim: To evaluate the effects of heparin on liver fibrosis in patients with chronic hepatitis B.
Methods: Fifty-two cases under study were divided into two groups, group A and group B. The two groups were given regular treatment and heparin/low molecular weight heparin (LMWH) treatment respectively.
[Effect of GFP/p53 fusion gene on the apoptosis of hepatocellular carcinoma cells].
Zhonghua Gan Zang Bing Za Zhi
June 2003
Aim: To investigate the apoptosis in gastric cancer cells induced by paclitaxel, and the relation between this apoptosis and expression of Bcl-2 and Bax.
Methods: In in vitro experiments, MTT assay was used to determine the cell growth inhibitory rate. Transmission electron microscope and TUNEL staining method were used to quantitatively and qualitively detect the apoptosis status of gastric cancer cell line SGC-7901 before and after the paclitaxel treatment.
Aim: To investigate the apoptosis in esophageal cancer cells induced by resveratrol, and the relation between this apoptosis and expression of Bcl-2 and Bax.
Methods: In in vitro experiments, MTT assay was used to determine the cell growth inhibitory rate. Transmission electron microscope and TUNEL staining method were used to quantitatively and qualitively detect the apoptosis status of esophageal cancer cell line EC-9706 before and after the resveratrol treatment.