Publications by authors named "Ju-Young Na"
Article Synopsis
- The study investigates the relationship between TFE3 and the PI3K/Akt pathway in renal cell carcinoma (RCC), focusing on how TFE3 expression is linked to cancer progression and patient prognosis.
- TFE3 was manipulated in UOK146 cells using siRNA, shRNA, and pcDNA3.1 to assess its effect on phospho-Akt levels when treated with mTOR and PI3K inhibitors.
- Results showed that TFE3 down-regulation increased phospho-Akt expression, while its up-regulation decreased it, suggesting that targeting the PI3K/Akt pathway could improve RCC treatment by impacting the tumor microenvironment.
Background: B7-H4 is expressed in various types of cancers and its expression inversely correlates with the degree of tumor-infiltrating lymphocytes (TILs). Studies have shown the relationship between B7-H4, cancer stem cell (CSC) properties, and epithelial-mesenchymal transition (EMT) in various cancers. However, very few studies have investigated the relationship between B7-H4, TILs, cancer stemness, and EMT in epithelial ovarian cancer (EOC).
View Article and Find Full Text PDFThe efficacy of programmed death ligand (PD-L)-1/PD-1 checkpoint blockade in renal cell carcinoma (RCC) remains unknown. The effects of mTOR inhibitors are uncertain, and patients may develop resistance to them. The limited understanding of cancer cell-intrinsic mTOR-mediated pathways remains a challenge in developing effective treatments.
View Article and Find Full Text PDFTransient global amnesia (TGA) is a temporary amnestic syndrome characterized by anterograde amnesia and variable retrograde amnesia without other focal neurological deficits. Neuropsychological tests during attack in TGA have been rarely reported. We report a 62-year-old man with TGA who was evaluated with detailed neuropsychological tests during attack.
View Article and Find Full Text PDFHashimoto's encephalopathy is an immune-mediated disorder characterized by acute or subacute encephalopathy related to increased anti-thyroid antibodies. Clinical manifestations of Hashimoto's encephalopathy may include stroke-like episodes, altered consciousness, psychosis, myoclonus, abnormal movements, seizures, and cognitive dysfunction. Acute cognitive dysfunction with convulsion as initial clinical manifestations of Hashimoto's encephalopathy is very rare.
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