Propofol inhibited the excitability of pyramidal neurons in the orbitofrontal cortex by influencing the delayed rectifier K+ channels and γ-aminobutyric acid type A receptors.

Propofol anesthesia caused loss of consciousness and cognitive decline. The neural mechanism for this phenomenon still remains elusive. Orbitofrontal cortex (OFC) plays a crucial role in controlling arousal and cognitive flexibility.

[The estrogen-like and antioxidant effects of pilose antler blood wine in female rats with ovariectomy].

Objective: To investigate whether pilose antler blood wine has the effects of estrogen-like activity and antioxidant in the ovariectomized (OVX) female rats.

Methods: The rat model of oxidative stress was established by ovariectomy. The female rats were divided into 6 groups: normal control group, OVX group, base wine group, and 3 pilose antler blood wine treated OVX groups (low, medium and high dose of wine at a dose of 4.