Publications by authors named "Ju-Jun Sun"
Purposes: We aimed to investigate the levels of CD4CD8 double positive (DP) T cells in patients with various severities of hemorrhagic fever with renal syndrome (HFRS), and the predictive capacity of DP T cells for the severity of this disorder.
Methods: The levels of DP T cells in 213 patients and 48 healthy donors were measured by flow cytometry, as were the levels of CD4 T cells, CD8 T cells, B lymphocytes, and natural killer (NK) cells. In each type of HFRS patient, we tested the basic clinical reference values for leukocytes, platelets, creatinine (Cr), uric acid (UA), and urea, and the values for activated partial thromboplastin time, prothrombin time, and fibrinogen, using conventional methods.
Article Synopsis
- Hantavirus, particularly Hantaan virus (HTNV), causes hemorrhagic fever with renal syndrome (HFRS), characterized by severe symptoms like low platelet counts and kidney issues.
- Current understanding of HFRS pathogenesis is limited, with immune dysfunction and damage to blood vessel linings thought to be key factors in disease development.
- The review explores various molecules involved in the immune response and vascular regulation, suggesting they could serve as indicators for monitoring HTNV infection and its related complications.