Binding-Free Taste Visualization with Plasmonic Metasurfaces.

Taste sensors using photonics, termed artificial photonic tongues, have emerged as a promising platform for intuitive taste discrimination. However, the need for complex binding protocols for each taste profile limits their applicability to a narrow range of taste molecules. Here, we introduce an intriguing "binding-free" approach to molecular taste sensing using plasmonics, eliminating the requirement for physical or chemical binding protocols.

Proton-Assisted Assembly of Colloidal Nanoparticles into Wafer-Scale Monolayers in Seconds.

Underwater adhesion processes in nature promise controllable assembly of functional nanoparticles for industrial mass production; However, their artificial strategies have faced challenges to uniformly transfer nanoparticles into a monolayer, particularly those below 100 nm in size, over large areas. Here a scalable "one-shot" self-limiting nanoparticle transfer technique is presented, enabling the efficient transport of nanoparticles from water in microscopic volumes to an entire 2-inch wafer in a remarkably short time of 10 seconds to reach near-maximal surface coverage (≈40%) in a 2D mono-layered fashion. Employing proton engineering in electrostatic assembly accelerates the diffusion of nanoparticles (over 50 µm/s), resulting in a hundredfold faster coating speed than the previously reported results in the literature.

Microplastic polyamide toxicity: Neurotoxicity, stress indicators and immune responses in crucian carp, Carassius carassius.

This study aimed to determine the toxicity standard and potential risks and effects of polyamide (PA) exposure on neurotoxicity, stress indicators, and immune responses in juvenile crucian carp Carassius carassius. Numerous microplastics (MPs) exists within aquatic environments, leading to diverse detrimental impacts on aquatic organisms. The C.

The application and future of biofloc technology (BFT) in aquaculture industry: A review.

This review describes the applicability of biofloc technology (BFT) to future aquaculture technologies. BFT is considered an innovative alternative for solving the problems of traditional aquaculture (for example, environmental pollution, high maintenance costs, and low productivity). Extensive research is being conducted to apply BFT to breed and raise many aquatic animal species.

KRG and its major ginsenosides do not show distinct steroidogenic activities examined by the OECD test guideline 440 and 456 assays.

Background: Ginseng has been used as a traditional medicine for treatment of many diseases and for general health maintenance. Previously, we showed that ginseng did not demonstrate estrogenic property in ovariectomized mouse model. However, it is still possible that disruption of steroidogenesis leading to indirect hormonal activity.

Toxic effects of microplastic (Polyethylene) on fish: Accumulation, hematological parameters and antioxidant responses in Korean Bullhead, Pseudobagrus fulvidraco.

Plastic waste discharged into the aquatic environment decomposes into microplastics (MP), which have toxic effects on fish species. Korean bullhead, Pseudobagrus fulvidraco is widely distributed in freshwater ecosystems in Korea, and it is important as an ecological indicator species to evaluate MP toxicity in Korea. In this study, the accumulation and physiological effects of juvenile P.

Biofloc Technology in Fish Aquaculture: A Review.

The application of biofloc to fish species has several advantages, including the enhancement of production by increasing growth performance and survival rate and the improvement of fish aquaculture physiological activity. There has been a recent increase in biofloc addition to fish culture, and this review examines changes this causes to the survival and growth rate of fish and its economic feasibility. Physiological activity and disease resistance of biofloc-fed fish is being extensively studied.

Enhancement of anticancer immunity by immunomodulation of apoptotic tumor cells using annexin A5 protein-labeled nanocarrier system.

Chemotherapy promotes phosphatidylserine (PS) externalization in tumors undergoing apoptosis, forms an immunosuppressive tumor microenvironment (TME), and inhibits dendritic cell (DC) maturation and antigen presentation by binding PS receptors expressed in DCs, thereby limiting naive T cell education and activation. In this study, we demonstrate a selective nanocarrier system composed of annexin A5-labeled poly (lactide-co-glycolide) nanoparticles (PLGA_NPs) encapsulating tumor specific antigen or neoantigen, to target apoptotic tumor cells expressing PS as an innate immune checkpoint inhibitor (ICI) that induces active cancer immunotherapy. Moreover, PLGA_NPs enhanced tumor-specific antigen-based cytotoxic T cell immunity via the original function of DCs by converting the tumor antigen-rich environment.

Immune checkpoint silencing using RNAi-incorporated nanoparticles enhances antitumor immunity and therapeutic efficacy compared with antibody-based approaches.

Background: Cytotoxic CD8 T cell-based cancer immunotherapy has been extensively studied and applied, however, tumor cells are known to evade immune responses through the expression of immune checkpoints, such as programmed death ligand 1 (PD-L1). To overcome these issues, antibody-based immune checkpoint blockades (eg, antiprogrammed cell death 1 (anti-PD-1) and anti-PD-L1) have been revolutionized to improve immune responses. However, their therapeutic efficacy is limited to 15%-20% of the overall objective response rate.

NIR irradiation-controlled drug release utilizing injectable hydrogels containing gold-labeled liposomes for the treatment of melanoma cancer.

Drug-based chemotherapy is associated with serious side effects. We developed a chemotherapeutic system comprising a chitosan hydrogel (CH-HG) containing gold cluster-labeled liposomal doxorubicin (DOX) (CH-HG-GL) as an injectable drug depot system. CH-HG-GL can be directly injected into tumor tissue without a surgical procedure, allowing this system to act as a reservoir for liposomal DOX.

Synergistic Neuroprotective Effects of Mature Silkworm and Against Scopolamine-Induced Mild Cognitive Impairment in Mice and HO-Induced Cell Death in HT22 Mouse Hippocampal Neuronal Cells.

We previously reported that mature silkworm (SW) ameliorated scopolamine (Sco)-induced amnesia, and (AG) prevented cognitive impairment. SW is known for its gastroprotective effects such as improving liver function and alleviating the effects of Parkinson's disease. AG is known for its neuroprotective effects and for lowering the effects of low-density lipoprotein cholesterol.

[Effect of a probiotic preparation (VSL#3) in patients with mild to moderate ulcerative colitis].

Background/aims: Ulcerative colitis (UC) is a chronic disease that characteristically has a relapsing and remitting course. Probiotics might possibly induce remission in the treatment of active UC. Aims of our study were to assess the efficacy of VSL#3 on clinical response and colonic tissue cytokine concentration changes in patients with active UC.

Expression and role of estrogen receptor alpha and beta in medullary thyroid carcinoma: different roles in cancer growth and apoptosis.

Medullary thyroid carcinoma (MTC) originates from parafollicular C cells. Estrogen receptor beta(ERbeta) expressionwas detected in normal parafollicular C cells and MTC tumor tissue, but ERalpha expression in MTC tumors still remains undetermined. The appearance and loss of ERalpha or ERbeta expression has been known to play a role in the development and progression of many human cancers.