Publications by authors named "Ju-Fang Cheng"
Article Synopsis
- Dementia with Lewy bodies (DLB) is a serious brain disorder characterized by the build-up of harmful proteins, including α-synuclein and amyloid β, leading to neuron death and a strong need for better treatments.
- The drug Ambroxol (AMBX) has shown promise in activating an enzyme called glucocerebrosidase, which helps clear toxic protein aggregates and improve cell health.
- In tests with brain cells exposed to these harmful proteins, AMBX was found to increase cell viability, restore enzyme activity, promote waste clearance, and reduce damage, indicating its potential as a treatment for DLB that needs further exploration in animal studies and clinical trials.
Background: Acute disseminated encephalomyelitis (ADEM) is an immune-mediated encephalopathy with heterogeneous disease courses. However, clinical characteristics for a prognostication of functional recovery from acute episodes of ADEM remain limited. The study aims to characterize the clinical presentations and neuroimaging findings of children with poor functional recoveries from acute episodes of moderate to severe ADEM.
View Article and Find Full Text PDFObjective: Pathogenic variants in DCX on the X chromosome lead to lissencephaly and subcortical band heterotopia (SBH), brain malformations caused by neuronal migration defects. Its product doublecortin (DCX) binds to microtubules to modulate microtubule polymerization. How pathogenic DCX variants affect these activities remains not fully investigated.
View Article and Find Full Text PDF