Publications by authors named "Ju Young Kim"

Introduction: Chronic cough is considered a disorder of neuronal hypersensitivity in which patients frequently report abnormal laryngeal and chest sensations, and excessive triggers. To facilitate clinical assessment, we developed the Cough Hypersensitivity Questionnaire (CHQ).

Methods: Candidate questionnaire items were developed following interviews with patients with refractory chronic cough (n=10, United Kingdom), and review by a multidisciplinary team.

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Despite significant advancements in all-solid-state batteries (ASSBs), the reliance on thick solid electrolyte (SE) membranes hinders their commercial viability. Although the dry process using polytetrafluoroethylene (PTFE) binder is proposed for thin SE membranes, a comprehensive understanding of the correlation between PTFE fibrillation and SE membrane quality remains lacking. Here an important guidance is provided for producing durable SE membranes that can be reduced to sub-20-µm thickness by regulating the entanglement networks of PTFE.

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  • Increasing environmental concerns are driving the development of microbial processes to produce glycolic acid (GA) using renewable resources instead of chemicals, but the existing Dahms pathway faces challenges in cell growth and GA yield.
  • A novel enzyme, AldA isolated from Buttiauxella agrestis (BaAldA), has shown improved performance over the existing AldA from E. coli, leading to significantly higher GA production.
  • This study highlights the effectiveness of metabolic flux balance analysis in identifying bottlenecks, paving the way for enhanced microbial production of various valuable compounds in future research.
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Background: Respiratory syncytial virus (RSV) is the leading cause of severe respiratory infections in infants worldwide, significantly affecting their health and contributing to the global healthcare burden. We aimed to examine healthcare resource utilisation patterns and costs for infants under one year old with confirmed RSV infection across subgroups of different gestational ages and health conditions and the cost implications of RSV infections over time, thereby demonstrating the economic burden of the disease.

Methods: This retrospective cohort study utilised nationwide claims data from the Korea Health Insurance Review and Assessment Service for infants under one year of age with confirmed RSV infection in the first year of life from January 2017 to April 2022.

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Introduction: Weight-loss strategies through meal replacements are effective and sustainable options. However, few studies have assessed their effects on weight loss including body composition through protein-supplemented meal replacements targeting the Asian population, including Koreans. This study aimed to assess the effectiveness and safety of a protein-supplemented very-low-calorie diet (PSVLCD) for weight reduction and changes in body composition in individuals with obesity over a 12-month long-term period.

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Fairness constitutes a cornerstone of social norms, emphasizing equal treatment and equitable distribution in interpersonal relationships. Unfair treatment often leads to direct responses and can spread to others through a phenomenon known as pay-it-forward (PIF) reciprocity. This study examined how unfairness spreads in interactions with new partners who have higher, equal, or lower status than the participants.

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  • - Sarcopenia, a condition characterized by muscle loss, can significantly impact the elderly, especially those with metabolic and inflammatory diseases; Vigeo, a plant extract, shows promise in counteracting muscle atrophy caused by dexamethasone (Dex). - In studies, Vigeo treatment was effective in reversing muscle loss in Dex-induced atrophy models, showing increases in calf muscle volume, weight, and cellular structure, along with protection against protein degradation linked to muscle wasting. - Vigeo also encourages muscle cell differentiation and activates important biochemical pathways for muscle maintenance and growth, indicating its potential role as a supplement or treatment to combat sarcopenia.
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  • * Sixty adults with MASLD were divided into two groups: one used the mobile app for interventions, while the other received standard educational materials, with liver enzyme levels assessed before and after 4 weeks.
  • * Results showed significant decreases in liver enzymes (alanine aminotransferase and gamma-glutamyl transferase) in the intervention group, suggesting that mobile lifestyle interventions could help improve liver health without impacting body weight or waist circumference, though more extensive studies are needed for confirmation.
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Resistin plays an important role in the pathophysiology of obesity-mediated insulin resistance in mice. However, the biology of resistin in humans is quite different from that in rodents. Therefore, the association between resistin and insulin resistance remains unclear in humans.

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Neuromodulation technologies are crucial for investigating neuronal connectivity and brain function. Magnetic neuromodulation offers wireless and remote deep brain stimulations that are lacking in optogenetic- and wired-electrode-based tools. However, due to the limited understanding of working principles and poorly designed magnetic operating systems, earlier magnetic approaches have yet to be utilized.

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Thermoelectric devices have received significant attention because of their potential for sustainable energy recovery. In these devices, a thermal design that optimizes heat transfer and dissipation is crucial for maximizing the power output. Heat dissipation generally requires external active or passive cooling devices, which often suffer from inevitable heat loss and heavy systems.

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  • The study explores how SCE, a traditional herbal extract, can enhance myoblast differentiation by activating mitochondrial biogenesis and protein synthesis pathways.* -
  • SCE was tested on murine C2C12 myoblast cells, showing no negative effects on cell viability while promoting myotube formation and increasing key muscle-specific proteins.* -
  • Findings indicate that SCE enhances expressions of important markers for muscle differentiation and growth, suggesting it could be a potential treatment for muscle loss and disorders.*
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Cytokines of the common-γ receptor chain (γ) family are crucial for T-cell differentiation and dysregulation of γ cytokine pathways is involved in the pathogenesis of autoimmune diseases. There is increasing evidence that the availability of the γ receptor (CD132) for the associated receptor chains has implications for T-cell functions. Here we studied the influence of differential γ expression on the expression of the IL-2Rα (CD25), the IL-7Rα (CD127) and the differentiation of activated naïve T cells.

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  • Rheumatoid arthritis (RA) is a chronic autoimmune disease leading to joint inflammation and destruction of cartilage and bone.
  • A study explored the effects of Vigeo, a fermented mixture, on RA symptoms using a collagen-induced arthritis (CIA) mouse model, where mice showed typical RA symptoms after treatment.
  • Results indicated that Vigeo significantly reduced joint inflammation and cartilage damage while lowering levels of inflammatory markers TNF-α, IL-6, and IL-1β in the serum, suggesting its potential as a therapeutic agent for RA.
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Porous thermoelectric materials offer exciting prospects for improving the thermoelectric performance by significantly reducing the thermal conductivity. Nevertheless, porous structures are affected by issues, including restricted enhancements in performance attributed to decreased electronic conductivity and degraded mechanical strength. This study introduces an innovative strategy for overcoming these challenges using porous BiSbTe (BST) by combining porous structuring and interface engineering via atomic layer deposition (ALD).

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  • - The study aimed to compare the effectiveness of CT-P13, a biosimilar to the original infliximab (IFX), on endoscopic healing (EH) and drug retention in children with inflammatory bowel disease (IBD).
  • - Researchers analyzed data from 416 pediatric IBD patients, finding no significant differences in clinical outcomes or adverse effects between those receiving the IFX originator and CT-P13 at one-year follow-up.
  • - Both treatments showed similar drug retention rates, with CT-P13 slightly outperforming the IFX originator in both Crohn's disease and ulcerative colitis cases, indicating comparable therapeutic responses.
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Current soft neural probes are still operated by bulky, rigid electronics mounted to a body, which deteriorate the integrity of the device to biological systems and restrict the free behavior of a subject. We report a soft, conformable neural interface system that can monitor the single-unit activities of neurons with long-term stability. The system implements soft neural probes in the brain, and their subsidiary electronics which are directly printed on the cranial surface.

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Purpose: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) serve as the standard first-line therapy for EGFR-mutated non-small cell lung cancer (NSCLC). Despite the sustained clinical benefits achieved through optimal EGFR-TKI treatments, including the third-generation EGFR-TKI osimertinib, resistance inevitably develops. Currently, there are no targeted therapeutic options available postprogression on osimertinib.

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A male in his 60s presented to the emergency department (ED) with a 3-week history of fever and progressive confusion. Initial laboratory and radiographic workup was largely unremarkable except for moderate bilateral pleural effusions. The patient was admitted on broad-spectrum antibiotics and further workup for fever of unknown aetiology.

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  • Excessive activity of osteoclasts during bone remodeling is linked to bone diseases like osteoporosis, making their inhibition a key therapeutic target.
  • Gryllus biomaculatus (GB) is an environmentally sustainable food source with known health benefits but its effects on osteoclast function were previously unexplored.
  • This study demonstrated that GB extract inhibits osteoclast formation and bone resorption by affecting various signaling pathways, providing a potential new treatment strategy for bone diseases.
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Chlorine (Cl)-containing chemicals, including hydrogen chloride, generated during thermal degradation of polyvinyl chloride (PVC) and corresponding mixture impede the chemical recycling of PVC-containing plastic wastes. While upgrading plastic-derived vapors, the presence of Cl-containing chemicals may deactivate the catalysts. Accordingly, herein, catalytic upgrading of pyrolysis vapor prepared from a mixture of PVC and polyolefins is performed using a fixed-bed reactor comprising zeolites.

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There has been significant research focused on the development of stretchable materials that can provide a large area with minimal material usage for use in solar cells and displays. However, most materials exhibit perpendicular shrinkage when stretched, which is particularly problematic for polymer-based substrates commonly used in stretchable devices. To address this issue, biaxial strain-controlled substrates have been proposed as a solution to increase device efficiency and conserve material resources.

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Developing soft robots that can control their own life cycle and degrade on-demand while maintaining hyperelasticity is a notable research challenge. On-demand degradable soft robots, which conserve their original functionality during operation and rapidly degrade under specific external stimulation, present the opportunity to self-direct the disappearance of temporary robots. This study proposes soft robots and materials that exhibit excellent mechanical stretchability and can degrade under ultraviolet light by mixing a fluoride-generating diphenyliodonium hexafluorophosphate with a silicone resin.

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People often align their behaviors and decisions with others' expectations, especially those of higher social positions, when they are being observed. However, little attention has been paid to the neural mechanisms underlying increased conformity to the social hierarchy under social observation. Using a preference rating task, we investigated whether and how individual preferences for novel stimuli were influenced by others' preferences by manipulating others' social hierarchy and observational context.

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