Publications by authors named "Ju Wan Kim"
Article Synopsis
- This longitudinal study analyzed how serum Brain-Derived Neurotrophic Factor (sBDNF) levels and childhood adversities affect the development of Post-Traumatic Stress Disorder (PTSD) in individuals with physical injuries over two years.
- Researchers assessed patients at a trauma center for sBDNF levels and childhood adversities using the ACE questionnaire and diagnosed PTSD at multiple intervals employing the Clinician-Administered PTSD Scale.
- Results showed that lower sBDNF levels increased the risk of earlier-onset PTSD among those who experienced childhood adversities, highlighting the importance of both biological and environmental factors in PTSD development.
Article Synopsis
- * Out of 538 participants, 58 (10.8%) developed PTSD, with rates decreasing over time from 8.4% at 3 months to 2.5% at 24 months.
- * Results showed that lower SDNN was linked to PTSD in patients who did not undergo surgery, suggesting that PTSD prevention strategies should take both SDNN levels and surgical status into account.
Background: This study investigated the longitudinal associations between serum BDNF (sBDNF) levels measured early after injury and the onset of post-traumatic stress disorder (PTSD) across two years.
Methods: Patients with moderate to severe physical injuries were enrolled from a trauma center. At baseline, sBDNF levels were measured and a comprehensive socio-demographic and clinical data were collected.
Article Synopsis
- The Clinician-Administered PTSD Scale (CAPS-5) is a reliable tool for diagnosing PTSD and was used in this study to assess its predictive value for PTSD development in patients with moderate to severe physical injuries over a 2-year period.
- 1,142 patients were evaluated for acute stress disorder at baseline, and follow-up assessments were conducted at multiple intervals using CAPS-5 to track PTSD development.
- Results indicated that while baseline CAPS-5 diagnoses showed limited predictive ability, scores of 15 or higher effectively predicted later PTSD, with scores of 16 or higher further increasing accuracy, especially in patients with intentional injuries or prior trauma.
Article Synopsis
- The study investigated how serum cortisol levels and personality traits impact the risk of developing PTSD over two years in individuals with physical injuries.
- It involved tracking 923 patients from a trauma center, measuring their cortisol levels and personality traits, while diagnosing PTSD at multiple intervals, showing that overall PTSD rates decreased over time.
- A significant finding revealed that lower cortisol levels combined with higher Neuroticism increased PTSD risk, especially in the early months, highlighting the complex relationship between biological factors and personality in PTSD development.
Delayed effects of alcohol consumption on the association between serum BDNF levels and post-traumatic stress disorder development over two-years.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Article Synopsis
- This study investigated how serum BDNF (sBDNF) levels and alcohol consumption status affect the risk of developing PTSD after a physical injury over a two-year period.
- It involved 923 trauma center participants, with 12.1% developing PTSD, revealing that lower sBDNF levels were linked to PTSD in alcohol consumers, but not in non-drinkers.
- The findings suggest a crucial interaction between sBDNF and alcohol consumption in predicting PTSD, emphasizing the importance of considering these factors in prevention strategies, although the study’s focus on a single trauma center may affect overall applicability.
Article Synopsis
- - The study explored factors that predict early-onset (within 6 months) and delayed-onset (after 6 months) PTSD in patients following physical injuries over two years.
- - Data was collected from 1142 patients in South Korea, assessing various personal, trauma-related, and psychological factors, with diagnoses made using the Clinician-administered PTSD Scale at multiple follow-up points.
- - Results showed that early-onset PTSD was more likely in individuals with previous psychiatric issues and higher anxiety, while delayed-onset PTSD was associated with greater injury severity and life stressors, highlighting the need for tailored interventions.
Article Synopsis
- Researchers investigated serum biomarkers to identify depression in patients with acute coronary syndrome (ACS), analyzing data from 969 individuals shortly after ACS and tracking 711 of them a year later.
- In the acute phase, 39% of patients showed depressive disorders, while 25.7% in the chronic phase; specific biomarkers correlated with these disorders were identified.
- The study suggested that particular serum biomarkers linked to inflammation and heart enzyme levels are significantly associated with depression, highlighting their potential role in diagnosing and managing emotional health post-ACS.
Two Cases of Posttraumatic Stress Disorder Caused by a Motor Vehicle Accident Treated with Virtual Reality Exposure Therapy.
Clin Psychopharmacol Neurosci
February 2024
Article Synopsis
- - Exposure-response prevention is a successful method for treating anxiety disorders, with virtual reality exposure therapy (VRET) showing promise for patients with posttraumatic stress disorder (PTSD) specifically linked to traffic accidents.
- - This study presents a specialized VRET protocol for individuals who developed PTSD after a traffic accident, showcasing two case studies that benefited from this treatment over six weeks.
- - Results indicated significant improvements in PTSD symptoms as well as reductions in depression, anxiety, and insomnia, highlighting the need for future research to implement controlled and randomized designs to validate these findings further.
Use of Serum Biomarkers to Aid Antidepressant Selection in Depressive Patients.
Clin Psychopharmacol Neurosci
February 2024
Article Synopsis
- This study sought to identify serum biomarkers that predict remission in out-patients with depressive disorders after 12 weeks of various antidepressant treatments.
- The research involved 1,024 patients using different antidepressants and measured 14 serum biomarkers along with clinical and demographic data to determine factors related to remission.
- Findings showed that specific lower levels of certain biomarkers were linked to remission for different types of antidepressants, suggesting that these markers can help guide treatment decisions for depression.
Neuroinflammation contributes to the pathophysiology of various mental illnesses including schizophrenia. We investigated peripheral inflammatory cytokines as a biomarker for predicting symptomatic remission in patients with first-episode schizophrenia. The study included 224 patients aged 15-60 years who fulfilled the criteria for schizophrenia spectrum disorder with a treatment duration ≤6 months.
View Article and Find Full Text PDFBackground: This study characterized coronavirus disease 2019 (COVID-19) vaccination behavior in the Korean general population using cluster analysis and explored related psychological factors.
Methods: We categorized 1,500 individuals based on their attitudes toward COVID-19 vaccination using hierarchical clustering and identified their level of vaccine acceptance. We examined the associations between vaccine acceptance and behavioral and psychological characteristics.
Objective: This study aimed to investigate COVID-19 vaccine acceptance and related factors in individuals with mental disorders in Korea.
Methods: We surveyed 572 individuals with mental disorders about their attitudes toward COVID-19 vaccination using a 7-item self-rating questionnaire on vaccine acceptance and hesitancy. We categorized the respondents into groups based on their level of vaccine acceptance using hierarchical clustering.