Publications by authors named "Ju Rong"

Background: Hyperoxia-induced injury is a well-recognized cause of bronchopulmonary dysplasia (BPD). Existing research studies have not well elucidated the exact mechanisms underlying hyperoxia-induced cellular damage. This study examines the involvement of the P2X7 receptor (P2X7R) in hyperoxia-induced damage to human pulmonary microvascular endothelial cells (HPMVECs) via the NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) pathway.

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Background: Primary abdominal pregnancy is an extremely rare form of ectopic pregnancy. Ectopic pregnancies that occur in the liver and diaphragm are even rarer, limited case reports are available in the literature.

Case Summary: A woman of childbearing age was transferred to the emergency department due to lumbar and abdominal pain radiating to the back toward the lower right.

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Background: At present, preterm infants with respiratory distress syndrome (RDS) in China present higher mortality and morbidity rates than those in high-income countries. The aim of this nationwide survey was to assess the clinical management of RDS in China.

Methods: A nationwide cross-sectional survey to assess adherence to RDS management recommendations was performed.

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Ocular neurodegenerative diseases like glaucoma lead to progressive retinal ganglion cell (RGC) loss, causing irreversible vision impairment. Neuroprotection is needed to preserve RGCs across debilitating conditions. Nerve growth factor (NGF) protein therapy shows efficacy, but struggles with limited bioavailability and a short half-life.

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Article Synopsis
  • Guilingji is a traditional Chinese medicine formula used for centuries to address aging and male sexual dysfunction, but there is limited clinical evidence supporting its effectiveness for idiopathic oligo-asthenoteratozoospermia (OAT).
  • A double-blind, randomized controlled study involving 240 patients evaluated the effects of Guilingji compared to a placebo over 12 weeks, focusing on sperm quality and metabolic changes.
  • Results showed significant improvements in sperm parameters and reduced oxidative stress indicators in patients taking Guilingji, along with notable changes in specific metabolites, suggesting potential therapeutic benefits for OAT.
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Background: Extremely preterm infants (EPIs) are at high-risk of white matter injury (WMI), leading to long-term neurodevelopmental impairments. We aimed to develop nomograms for WMI.

Methods: The study included patients from 31 provinces, spanning ten years.

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The management of infected wounds poses a significant challenge due to the growing issue of antibiotic resistance, underscoring the urgent necessity to innovate and implement alternative therapeutic strategies. These strategies should be capable of eliminating bacterial infections in infected wounds while circumventing the induction of multi-drug resistance. In the current study, we developed an easily prepared and injectable fibrin gel (FG) loaded with nanoparticles (NPs) that exhibit antibacterial and immunomodulatory properties to facilitate the healing of infected wounds.

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Background: The occurrence of severe intraventricular hemorrhage (sIVH) was high in the very preterm infants (VPIs) in China. The management strategies significantly contributed to the occurrence of sIVH in VPIs. However, the status of the perinatal strategies associated with sIVH for VPIs was rarely described across the multiple neonatal intensive care units (NICUs) in China.

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Article Synopsis
  • - The study focused on creating a real-time risk prediction model for extrauterine growth retardation (EUGR) in very preterm infants, utilizing data from 2,514 infants split into training and validation sets.
  • - Key predictors, including birth weight, small for gestational age, and others, were identified and used in a logistic regression model, with a nomogram visualization to help assess risk.
  • - The model demonstrated strong predictive ability, achieving ROC curve areas of 83.1% and 84.6% for the training and validation sets, respectively, and indicating good calibration and clinical applicability for risk assessment.
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Polycystic ovary syndrome (PCOS) is a condition resulting from the interaction between environmental factors and hereditary components, profoundly affecting offspring development. Although the etiology of this disease remains unclear, aberrant in utero androgen exposure is considered one of the pivotal pathogenic factors. Herein, we demonstrate the intergenerational inheritance of PCOS-like phenotypes in F2 female offspring through F1 males caused by maternal testosterone exposure in F0 mice.

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Objective: To assess the predictive value of the serum lipid profile for initial intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs) in patients with Kawasaki disease (KD).

Methods: This retrospective cohort study enrolled patients with KD and divided them into IVIG-responsive and IVIG-resistant groups. They were also stratified based on the presence of CALs (CALs and non-CALs groups).

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Estrogen plays a multifaceted function in humans via interacting with the estrogen receptors ERα, ERβ, and G protein-coupled estrogen receptor 1 (GPER1). Previous research has predominantly concentrated on elucidating the signaling route of estrogen. However, the comprehensive understanding of the expression profile and control of these estrogen receptors in various human tissues is not well known.

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  • The study investigates risk factors for severe bronchopulmonary dysplasia (BPD) in very preterm infants (VPIs) in China, highlighting its high mortality association.
  • Using data from 7 regions, the research categorizes infants with BPD based on their oxygen requirements and identifies risk factors through logistic regression.
  • Key findings show that low gestational age and birth weight are significant risk factors, while long-term mechanical ventilation, multiple blood transfusions, and infections contribute to severe BPD; however, antenatal steroids may lower the risk.
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Increased cellular senescence burden contributes in part to age-related organ dysfunction and pathologies. In our study, using mouse models of natural aging, we observed structural and functional decline in the aged retina, which was accompanied by the accumulation of senescent cells and senescence-associated secretory phenotype factors. We further validated the senolytic and senomorphic properties of procyanidin C1 (PCC1) both in vitro and in vivo, the long-term treatment of which ameliorated age-related retinal impairment.

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Virus-like particles (VLP) are a promising tool for intracellular gene delivery, yet their potential in ocular gene therapy remains underexplored. In this study, we bridged this knowledge gap by demonstrating the successful generation and application of vesicular stomatitis virus glycoprotein (VSVG)-pseudotyped mouse PEG10 (MmPEG10)-VLP for intraocular mRNA delivery. Our findings revealed that PEG10-VLP can efficiently deliver GFP mRNA to adult retinal pigment epithelial cell line-19 (ARPE-19) cells, leading to transient expression.

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Single-metal-site catalysts have recently aroused extensive research in electrochemical energy fields such as zinc-air batteries and water splitting, but their preparation is still a huge challenge, especially in flexible catalyst films. Herein, we propose a sublimation strategy in which metal phthalocyanine molecules with defined isolated metal-N sites are gasified by sublimation and then deposited on flexible single-wall carbon nanotube (SWCNT) films by means of π-π coupling interactions. Specifically, iron phthalocyanine anchored on the SWCNT film prepared was directly used to boost the cathodic oxygen reduction reaction of the zinc-air battery, showing a high peak power density of 247 mW cm.

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Background: Hyperglycemia in pregnancy (HGP) has generally been considered a risk factor associated with adverse outcomes in offspring, but its impact on the short-term outcomes of very preterm infants remains unclear.

Methods: A secondary analysis was performed based on clinical data collected prospectively from 28 hospitals in seven regions of China from September 2019 to December 2020. According to maternal HGP, all infants were divided into the HGP group or the non-HGP group.

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Squamous intraepithelial lesion of cervix (SIL) in human papillomavirus (HPV)-positive patient often undergoes a silent and long-course development, and most of them with high-grade transit to cervical squamous cell carcinoma (CSCC). The oxysterol 25-hydroxycholesterol (25-HC) is associated with HPV inhibition, autophagy and cholesterol synthesis, however, its function in this long process of SIL development remain unclear. In this study, we demonstrate that 25-HC generation is inhibited through HSIL-to-CSCC transition.

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  • NEC is a serious illness that mostly affects premature babies, showing up usually after they are a week old.
  • This study looked at data from over 2,500 premature babies to understand the causes of late-onset NEC and how it affects their health in the short term, especially focusing on their nutrition.
  • Results showed that babies with late-onset NEC faced more health issues like anemia and required more treatments, had slower weight gain, and breastfeeding rates were lower among them.
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Schlemm's canal (SC) functions to maintain proper intraocular pressure (IOP) by draining aqueous humor and has emerged as a promising therapeutic target for glaucoma, the second-leading cause of irreversible blindness worldwide. However, our current understanding of the mechanisms governing SC development and functionality remains limited. Here, we show that vitronectin (VTN) produced by limbal macrophages promotes SC formation and prevents intraocular hypertension by activating integrin αvβ3 signaling.

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Purpose: TGF-β/BMP signaling pathway plays a significant role in fibrotic cataract. Smurf1, a ubiquitin protein ligase, regulates the TGF-β/BMP signaling pathway through the ubiquitin-proteasome system (UPS). This study aims to investigate the role of Smurf1 in the progression of fibrotic cataract and its underlying mechanism.

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  • The study aimed to evaluate and compare the effectiveness and safety of non-invasive high-frequency oscillatory ventilation (NHFOV) and nasal continuous positive airway pressure (NCPAP) in preterm infants.
  • A meta-analysis of ten randomized controlled trials involving 2,031 preterm infants showed that NHFOV significantly reduced intubation or reintubation rates compared to NCPAP, with no notable increase in complications.
  • The findings suggest that NHFOV is a more effective intervention for managing respiratory support in preterm infants compared to NCPAP, as indicated by lower intubation rates and similar complication levels.
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Rechargeable lithium-ion batteries, as the most advanced energy storage devices currently available, urgently require the development of cathode materials with high capacity, large specific energy, and fast charge/discharge performance to satisfy the continuous technological innovation. Here, a Li-rich Mn-based ternary cathode material LiNiCoMnO is designed, and the geometrical structure, electronic properties, and thermodynamic properties of this material are investigated employing the first-principles method. Six layered structure models are established by adjusting the ratio of Ni, Co, and Mn elements, and the effects of various elements on the material properties are evaluated.

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The SrCoO system has broad application potential due to its diverse crystal structures, oxidation stoichiometric ratio, and significant electrical and magnetic properties. However, it faces the challenges of a complex crystal structure and oxygen defect control in this material system. Herein, we introduce oxygen defects into SrCoO Er doping to regulate the structural, electrical and magnetic transport properties.

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