Simulation and prediction of changes in maximum freeze depth in the source region of the Yellow River under climate change.

The source region of the Yellow River (SRYR) is located at the edge of the Qinghai-Tibet Plateau (QTP), which is completely covered by frozen ground. Due to relatively higher temperatures, the frozen ground in the SRYR is particularly fragile and susceptible to the impacts of global climate change. This study discusses the maximum freeze depth (MFD) of frozen ground in the SRYR, including analysis of measured data at the stations, comparison of simulation models, and projection of future changes.

Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis.

Background: Accumulating evidence has demonstrated that aberrant expression of deubiquitinating enzymes is associated with the initiation and progression of Triple-negative breast cancer (TNBC). The publicly available TCGA database of breast cancer data was used to analyze the OTUD deubiquitinating family members that were correlated with survival of breast cancer and ovarian tumor domain-containing 2 (OTUD-2), or YOD1 was identified. The aim of present study was to assess YOD1 expression and function in human TNBC and then explored the underlying molecular events.

Changes in permafrost spatial distribution and active layer thickness from 1980 to 2020 on the Tibet Plateau.

The Tibetan Plateau (TP) is experiencing extensive permafrost degradation due to climate change, which seriously threatens sustainable water and ecosystem management in the TP and its downstream areas. Understanding the evolution of permafrost is critical for studying changes in the water cycle, carbon flux, and ecology of the TP. In this study, we mapped the spatial distribution of permafrost and active layer thickness (ALT) at 1 km resolution for each decade using empirical models and machine learning methods validated with borehole data.

Vegetation Changing Patterns and Its Sensitivity to Climate Variability across Seven Major Watersheds in China.

Climate changes have profound impacts on vegetation and further alter hydrological processes through transpiration, interception, and evaporation. This study investigated vegetation's changing patterns and its sensitivity to climate variability across seven major watersheds in China based on a hybrid regionalization approach and a novel, empirical index-Vegetation Sensitivity Index (VSI). Vegetation showed linearly increasing trends in most of the seven watersheds, while decreases in vegetation were mostly found in the source regions of the Yangtze River Basin (YZRB) and Yellow River Basin (YRB), the forest and grassland areas of the Songhua River Basin (SHRB) and Liao River Basin (LRB), the Yangtze River Delta, and the Pearl River Delta during the growing season.

Koehne in Sichuan, China: Recorded History as a Medicine and Food, Modern Applications, Distribution, and Ethnobotanical Investigations.

Koehne, a plant in the Rosaceae family, is named ཁམབུ། in Tibetan and "Guang he tao" in Chinese. It is mainly distributed in Tibet Autonomous Region, Yunnan Province, and Sichuan Province in China. It is also a rare "living fossil group" of peach genetic resources in the world.

Quantified hydrological responses to permafrost degradation in the headwaters of the Yellow River (HWYR) in High Asia.

The impact on the hydrologic cycle of permafrost degradation under the influence of climate change has caused an inestimable threat to sustainable regulation of the ecosystem. This study quantified the responses of main hydrological elements, including soil moisture, groundwater, runoff components and discharge to totally degraded permafrost in eastern High Asia by establishing cases with and without thermodynamics using a cold region model combining hydrological processes and thermodynamics. The results showed that the model successfully simulated discharge in cold region basins.

Redox modulated fluorometric sensing of ascorbic acid by using a hybrid material composed of carbon dots and CoOOH nanosheets.

Carbon dots (CDs) were hydrothermally prepared from gelatin as the sole precursor. The CDs were hybridized with CoOOH nanosheets (NSs) to obtain a fluorescent probe (CD-CoOOH) for ascorbic acid (AA). The blue luminescence of the CDs, with excitation/emission maxima of 350/443 nm, is quenched by the NSs.

Powder carbonization to synthesize novel carbon dots derived from uric acid for the detection of Ag(I) and glutathione.

This article first reported that a simple synthesis of carbon dots (UCDs) by pyrolysis of uric acid was proposed. The excitation wavelength was 350 nm and the emission wavelength was 402 nm for the synthesized UCDs. And the corresponding fluorescence quantum yield was 52.

Bright carbon dots via inner filter effect for the sensitive determination of the purine metabolic disorder in human fluids.

In this paper, the high performance fluorescent carbon dots were synthesized with maleic acid, tris and benzoic acid as raw materials by one-step hydrothermal method. The obtained carbon dots with uniform size emitted strong blue fluorescence, which the maximum excitation and emission wavelengths at 250 nm and 415 nm, respectively. Under the optimum condition, it was meaningfully founded that the reaction between the carbon dots and uric acid resulting in the fluorescence quenching of the carbon dots at the emission spectrum of 415 nm.

Vitamin D deficiency may predict a poorer outcome of IgA nephropathy.

Background: Experimental studies showed that 25-hydroxy-vitamin D [25(OH)D] deficiency (defined as 25-hydroxy-vitamin D < 15 ng/ml) has been associated with CKD progression. Patients with IgA nephropathy have an exceptionally high rate of severe 25(OH)D deficiency; however, it is not known whether this deficiency is a risk factor for progression of IgA nephropathy. We conducted this study to investigate the relationship between the plasma level of 25(OH)D and certain clinical parameters and renal histologic lesions in the patients with IgA nephropathy, and to evaluate whether the 25(OH)D level could be a good prognostic marker for IgA nephropathy progression.

[Application of computer-aided diagnosis in early detection of pulmonary nodules based on digital chest radiograph].

This study aims to explore the clinical value of the computer-aided diagnosis (CAD) system for early detection of the pulmonary nodules on digital chest X-ray. A total of 100 cases of digital chest radiographs with pulmonary nodules of 5-20 mm diameter were selected from Pictures Archiving and Communication System (PACS) database in West China Hospital of Sichuan University were enrolled into trial group, and other 200 chest radiographs without pulmonary nodules as control group. All cases were confirmed by CT examination.

Characteristics and scenarios projection of climate change on the Tibetan Plateau.

The Fourth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC AR4) presents twenty-two global climate models (GCMs). In this paper, we evaluate the ability of 22 GCMs to reproduce temperature and precipitation over the Tibetan Plateau by comparing with ground observations for 1961~1900. The results suggest that all the GCMs underestimate surface air temperature and most models overestimate precipitation in most regions on the Tibetan Plateau.