Medaka () Is Involved in Male Fertility.

Research across various species has demonstrated that the doublesex and mab-3-related transcription factor 3 () plays pivotal roles in testis development. However, the precise molecular mechanisms of remain unclear. In this study, we investigated the role of () in testis development using the model organism medaka ().

Immunophenotype of myeloid granulocytes in Chinese patients with BCR::ABL1-negative myeloproliferative neoplasms.

Typical BCR::ABL1-negative myeloproliferative neoplasms (MPN) are mainly referred to as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofbrosis (PMF). Granulocytes in MPN patients are involved in their inflammation and form an important part of the pathophysiology of MPN patients. It has been shown that the immunophenotype of granulocytes in MPN patients is altered.

Advances in hematopoietic stem cells ex vivo expansion associated with bone marrow niche.

Hematopoietic stem cells (HSCs) are an ideal source for the treatment of many hematological diseases and malignancies, as well as diseases of other systems, because of their two important features, self-renewal and multipotential differentiation, which have the ability to rebuild the blood system and immune system of the body. However, so far, the insufficient number of available HSCs, whether from bone marrow (BM), mobilized peripheral blood or umbilical cord blood, is still the main restricting factor for the clinical application. Therefore, strategies to expand HSCs numbers and maintain HSCs functions through ex vivo culture are urgently required.

Mindful parenting and closeness in Chinese mother-adolescent dyads: The mediating role of adolescent self-disclosure.

Although having strong influences on adolescents' optimal development, mother-adolescent closeness is greatly challenged in early adolescence. Mindful parenting may be a protective factor for relational adjustment to early adolescence, but its connection with closeness within the mother-adolescent dyad has not been adequately examined in the literature. This study aimed to investigate the effects of how mindful parenting on the day-to-day mother-adolescent relationship dynamics, evaluating the relations between mindful parenting and mother-adolescent closeness and the mediating role of adolescent self-disclosure.

[The Inhibiting Effect of Autophagy Inhibitor ROC-325 on Multiple Myeloma].

Objective: To investigate the effects of autophagy inhibitor ROC-325 and its combination with bortezomib on the proliferation, apoptosis and autophagy of multiple myeloma cell lines.

Methods: Multiple myeloma cells were treated with ROC-325 at different concentration. The cell proliferation was detected by CCK-8.

The Association Between Mindful Parenting and Adolescent Internalizing and Externalizing Problems: The Role of Mother-Child Communication.

This study aimed to explore the mediation process from maternal mindful parenting to adolescent internalizing and externalizing problems through mother-child communication and adolescent self-disclosure. A total of 496 mother-adolescent dyads participated in the current study. Mother-reported mindful parenting and mother-child communication and adolescent-reported self-disclosure and behavior problems were collected.

A daily diary study of the relationships among daily self-compassion, perceived stress and health-promoting behaviours.

Previous studies consistently found that trait self-compassion is positively associated with health-promoting behaviours, and perceived stress mediates the relationship. The current study primarily aimed at examining whether state self-compassion varying from day to day (daily self-compassion) played the same role as trait self-compassion in improving health-promoting behaviours and whether or not perceived stress would be the mediator in this relationship. Eighty-nine Chinese employees were recruited to finish demographic information and the trait measure of self-compassion first, and then finish daily diaries for seven consecutive days.

Remission of Microscopic Polyangiitis Using Traditional Chinese Medicine: A Case Report.

Microscopic polyangiitis (MPA) is a systemic disease described as necrotizing vasculitis that affects capillaries, venules and arterioles. Hormone-based immunosuppression therapy is the common treatment, but with severe side effects. Hence, non-hormone or low-hormone therapies may be another option.

Targeted Synthesis of Unique Nickel Sulfide (NiS, NiS) Microarchitectures and the Applications for the Enhanced Water Splitting System.

Water splitting is one of the ideal technologies to meet the ever increasing demands of energy. Many materials have aroused great attention in this field. The family of nickel-based sulfides is one of the examples that possesses interesting properties in water-splitting fields.

Resveratrol ameliorates cardiac dysfunction induced by pressure overload in rats via structural protection and modulation of Ca(2+) cycling proteins.

Background: Cardiac hypertrophy is a compensatory stage of the heart in response to stress such as pressure overload (PO), which can develop into heart failure (HF) if left untreated. Resveratrol has been reported to prevent the development of hypertrophy and contractile dysfunction induced by PO. However, other studies found that resveratrol treatment for a longer period of time failed to regress cardiac hypertrophy.