RESTRUCTURING OF SKELETAL MUSCLE, LUNG AND HEART TISSUES OF RATS UNDER HYPOXIA TRAINING.

We studied some specific features of the changes in mor- pho- and stereometric characteristics of the ultrastructure of tissues of lungs, heart, and muscles, their capillarization, and the mitochondrial apparatus of cells in adult male Wistar rats under long-term physical loads. It is shown that the influence of a sustained training accompanied by the development of exercise-induced hypoxia on the structural readjustments of tissues of muscles, lungs, and myocardium can be conditionally divided into 2 groups: with destructive and compensatoryadaptive features. The changes with destructive character include, firstly, those of the ultrastructure of biological bar- riers such as, in particular, hyperhydration of barriers on the whole and their separate layers, which deteriorates the conditions of oxygen diffusion; second, the destructive changes in mitochondria (it increased the number of damaged lung organelles by 4.

[Vascular endothelial growth factor during physical loads with different mechanism of energy's providing of muscular work].

In the article the results of investigation of vascular endothelial growth factor's (VEGF) maintenance changes at the oxidative stress caused by physical activities and associated tissue hypoxia, for the representatives of types of sport with the different mechanisms of energy providing of muscular work are presented. The highest VEGF concentration of serum was marked in sports with representatives of aerobic energy supply mechanism of muscle activity--from 122.8±3.