The interaction of nutrient uptake with biotic and abiotic stresses in plants.

Plants depend heavily on efficient nutrient uptake and utilization for optimal growth and development. However, plants are constantly subjected to a diverse array of biotic stresses, such as pathogen infections, insect pests, and herbivory, as well as abiotic stress like drought, salinity, extreme temperatures, and nutrient imbalances. These stresses significantly impact the plant's ability to take up nutrient and use it efficiency.

Quantum Computing in Community Detection for Anti-Fraud Applications.

Fraud detection within transaction data is crucial for maintaining financial security, especially in the era of big data. This paper introduces a novel fraud detection method that utilizes quantum computing to implement community detection in transaction networks. We model transaction data as an undirected graph, where nodes represent accounts and edges indicate transactions between them.

Full-Endoscopic J-Shaped Transforaminal L5 Nerve Decompression in Bertolotti Syndrome.

This case report and video demonstrate the technique of full-endoscopic J-shaped transforaminal L5 exiting nerve decompression in Bertolotti syndrome. Bertolotti syndrome, characterized by a congenital lumbosacral transitional vertebra, often results in mechanical lower back pain and nerve root compression. A 69-year-old male presented with progressive radiating pain in the right leg and tingling in the L5 dermatome.

[Pulmonary Kaposi sarcoma after lung transplantation: a case report and literature review].

To investigate the clinical features, diagnosis, and treatment of pulmonary Kaposi sarcoma (KS) after lung transplantation. A case of pulmonary KS after bilateral lung transplantation was retrospectively analyzed. Two key words "Kaposi sarcoma" and "lung transplant*" were used to search for relevant literature in SinoMed, Wanfang Data, CNKI, PubMed, Embase, Cochrane Library and Web of Science, with a cut-off date of July 31, 2024.

Characterizing Vericiguat Treatment in Heart Failure: A Multicenter Real-World Study in China.

Background: Real-world data on the clinical benefit of vericiguat are currently limited. This multicenter, real-world study was conducted to evaluate the clinical characteristics and therapeutic effects of vericiguat in real-world settings.

Methods: This study analyzed heart failure (HF) patients who initiated vericiguat treatment from September 2022 to August 2023 across nine hospitals in the Anhui Province, China.

The N-terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism.

Background: The emerging incidence of pathogenic liver conditions is turning into a major concern for global health. Induction of pyroptosis in hepatocytes instigates cellular disintegration, which in turn liberates substantial quantities of pro-inflammatory intracellular substances, thereby accelerating the advancement of liver fibrosis. Consequently, directing therapeutic efforts towards inhibiting pyroptosis could potentially serve as an innovative approach in managing inflammation related chronic hepatic disorders.

Targeted microbiota dysbiosis repair: An important approach to health management after spinal cord injury.

Current research primarily focuses on the pathological mechanisms of spinal cord injury (SCI), seeking to promote spinal cord repair and restore motorial and sensory functions by elucidating mechanisms of cell death or axonal regeneration. However, SCI is almost irreversible, and patients often struggle to regain mobility or self-care abilities after injuries. Consequently, there has been significant interest in modulating systemic symptoms following SCI to improve patients' quality of life.

Respiratory Physiological Reactions During Expiratory Muscle Training in Patients with Stable Severe Chronic Obstructive Pulmonary Disease (COPD).

Object: This study aimed to investigate the physiological responses of patients with severe Chronic Obstructive Pulmonary Disease (COPD) during incremental expiratory resistive loading (ERL).

Method: Nine stable subjects with very severe COPD and hypercapnia were recruited. Baseline data were collected through spontaneous breathing for 10 minutes without resistive load.

Multiple Polarization States in Hf ZrO Thin Films by Ferroelectric and Antiferroelectric Coupling.

HfO-based multi-bit ferroelectric memory combines non-volatility, speed, and energy efficiency, rendering it a promising technology for massive data storage and processing. However, some challenges remain, notably polarization variation, high operation voltage, and poor endurance performance. Here we show Hf ZrO (x = 0.

[Analysis on Spatial-temporal Characteristics and Driving Factors of PM in Heilongjiang Province in the Past 20 years].

PM is an important indicator for measuring the degree of air pollution. Studying the space-time variation and the driving factors of spatial heterogeneity is important for controlling air pollution and improving regional air quality. Based on PM remote sensing data from 2000 to 2021, the Theil-Sen Median trend analysis, Mann-Kendall significant inspection, and spatial auto correlation were used to analyze the characteristics of space-time changes in PM concentration, and geographical detectors were combined with a multi-scale geographical weighted regression model to explore the key driver factor and its influence and direction of the impact and role of PM spatial differences.

Single-cell analysis combined with transcriptome sequencing identifies autophagy hub genes in macrophages after spinal cord injury.

Spinal cord injury (SCI) is a neurological disease characterized by the loss of motor and sensory function below the injury level. The pathogenesis of SCI is complex, involving the recruitment of various cells that play key roles in the injury area. Single-cell RNA sequencing (scRNA-seq) can analyze cell heterogeneity and inter-cell communication.

Unraveling the Diffusion MRI-Based Glymphatic System Alterations in Children with Rolandic Epilepsy.

Rationale And Objectives: Although dysfunction of the glymphatic system in adult epilepsy has been extensively studied, there is a lack of research on the changes in this system during childhood development, particularly in children with Rolandic epilepsy (RE). This study aimed to investigate the changes in diffusion MRI measures related to the glymphatic function in children with RE.

Materials And Methods: A total of thirty-eight children with RE and thirty-six demographically matched healthy children were enrolled in the study.

Topological beam splitter based on 2D PC with different beam splitting angles.

Photonic devices are prone to reflection losses at defects and corners. Topological photonics proposes robustness of transmission to improve transmission efficiency. In this work, a dielectric photonic crystal structure based on the quantum spin Hall effect is proposed, which has a large topological bandwidth.

Semantic-empowered visible light communication for image transmission based on deep convolutional generative adversarial network.

In this paper, a semantic communication-based scheme was proposed to tackle the optimization challenge of transmission efficiency and link stability in indoor visible light communication (VLC) systems utilizing light-emitting diodes for image transmission. The semantic model, established by deep convolutional generative adversarial network (DCGAN) and vector quantization method, can effectively extract the essential characteristics of images. In addition, indoor VLC channel models including line-of-sight (LOS) and non-line-of-sight (NLOS) links are established in a 5*5*3 room, while incorporating noise interference encountered during signal transmission into the training process of the semantic model to enhance its anti-interference capability.

Inverse Vulcanization of Aziridines: Enhancing Polysulfides for Superior Mechanical Strength and Adhesive Performance.

This study introduces a novel approach to inverse vulcanization by utilizing a commercially available triaziridine crosslinker as an alternative to conventional olefin-based crosslinkers. The model reactions reveal a self-catalyzed ring-opening of "unactivated" aziridine with elemental sulfur, forming oligosulfide-functionalized diamines. The triaziridine-derived polysulfides exhibit impressive mechanical properties, achieving a maximum stress of ~8.

Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway.

Fibroblast activation plays an important role in the occurrence and development of idiopathic pulmonary fibrosis (IPF), which is a progressive, incurable, and fibrotic lung disease. However, the underlying mechanism of fibroblast activation in IPF remains elusive. Here, we showed that the expression levels of STX11 and SNAP25 were downregulated in the lung tissues from patients with IPF and mice with bleomycin (BLM)-induced lung fibrosis as well as in the activated fibroblasts.

Low-cost high-throughput targeted sequencing for the accurate detection of respiratory tract pathogens.

Introduction: The current gold standard for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnosis by real-time reverse transcriptase polymerase chain reaction (RT-PCR) is limited by the number of genes that can be detected. In this study, we developed a low-cost and high-throughput next-generation sequencing technology that can overcome the limitations of real time RT-PCR.

Methodology: A targeted sequencing panel (TSP) consisting of approximately 500 amplicons was designed.

ChemXTree: A Feature-Enhanced Graph Neural Network-Neural Decision Tree Framework for ADMET Prediction.

The rapid progression of machine learning, especially deep learning (DL), has catalyzed a new era in drug discovery, introducing innovative approaches for predicting molecular properties. Despite the many methods available for feature representation, efficiently utilizing rich, high-dimensional information remains a significant challenge. Our work introduces ChemXTree, a novel graph-based model that integrates a Gate Modulation Feature Unit (GMFU) and neural decision tree (NDT) in the output layer to address this challenge.

Associations of Serum Lipid Traits With Fracture and Osteoporosis: A Prospective Cohort Study From the UK Biobank.

Background: Previous studies reveal inconsistent associations between serum lipid traits and the risks of fractures and osteoporosis in the general population.

Methods: This prospective cohort study analysed data from 414 302 UK Biobank participants (223 060 women and 191 242 men, aged 37-73 years) with serum lipid measurements: apolipoprotein A (Apo A), apolipoprotein B (Apo B), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and lipoprotein A (Lp(a)). Multivariable Cox proportional hazard models with penalized cubic splines were used to explore potential nonlinear associations of each lipid trait with the risks of fractures and osteoporosis.

Arabidopsis calcium-dependent protein kinases 4/5/6/11 negatively regulate hydrotropism via phosphorylation of MIZU-KUSSEI1.

Hydrotropism facilitates the orientation of plant roots toward regions of elevated water potential, enabling them to absorb adequate water. Although calcium signaling plays a crucial role in plant response to water tracking, the exact regulatory mechanisms remain a mystery. Here, we employed the Arabidopsis (Arabidopsis thaliana) hydrotropism-specific protein MIZU-KUSSEI1 (MIZ1) as bait and found that calcium-dependent protein kinases 4/5/6/11 (CPK4/5/6/11) interacted with MIZ1 in vitro and in vivo.

Photobiomodulation reduces spinal cord edema by decreasing the expression of AQP4 in the astrocytes of male spinal cord injury rats via the JAK2/STAT3 signaling pathway.

Background: Spinal cord swelling commonly occurs following SCI. Previous studies suggest that PBM may reduce inflammation and scar formation after SCI. However, whether PBM can alleviate post-spinal cord injury edema and its underlying mechanisms have not yet been reported.

Investigating the mechanism of enhanced medicinal effects of Terminalia chebula fruit after processing based on intestinal flora and metabolomics.

Background And Objective: Terminalia chebula is a classical medicine for the treatment of lingering dysentery, and both raw and processed T. chebula can alleviate ulcerative colitis (UC). The therapeutic efficacy of T.