Publications by authors named "Jp Singh"

Long-term electrocardiogram (ECG) monitoring is crucial for detecting and diagnosing cardiovascular diseases (CVDs). Monitoring cardiac health and activities using efficient, noninvasive, and cost-effective techniques such as ECG can be vital for the early detection of different CVDs. Wet electrode-based traditional ECG techniques come with unavoidable limitations of the altered quality of ECG signals caused by gel volatilization and unwanted noise followed by dermatitis.

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We have grown (111)- and (001)-oriented NiO thin films on (0001)-Sapphire and (001)-MgO substrates using pulsed laser deposition (PLD), respectively. DC magnetic susceptibility measurements underline that the Néel temperatures of the samples are beyond room-temperature. This is further confirmed by the presence of two-magnon Raman scattering modes in these films in ambient conditions.

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Background: Barriers to maximizing patient benefit with implantable defibrillation devices include limited ability to tailor antitachycardia pacing (ATP) therapy in real-time and identify patients at risk of heart failure (HF) events early on. The Personalized Therapy study aims to evaluate the performance of two algorithms, intrinsic ATP (iATP) and TriageHF, to address these barriers in routine clinical practice.

Methods And Results: The Personalized Therapy Study was designed as a prospective, multicenter, post-market registry study expected to enroll approximately 2,200 patients meeting the following criteria: (1) implanted with a study-eligible device regardless of procedure type; (2) Medtronic CareLink® Network enrolled; (3) TriageHF enabled within CareLink and High Risk Alert notifications turned ON; and (4) iATP enabled.

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This article discusses the literature review article by Pacheco published in July 2024; the authors provided good reviews of perianal Crohn's disease (CD), and challenges faced by clinicians in the management. CD, characterized by its chronic and relapsing nature, is an idiopathic condition that can involve any segment of the gastrointestinal tract. Perianal disease impacts up to 40% of patients with CD, with perianal fistulas constituting up to 80% of perianal lesions.

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Enantioselective discrimination is critical in several fields, particularly in pharmaceutics and clinical drug research. Chiral molecules possess unique charge transfer properties, showing an enantioselective preference for electron spin orientation when interacting with the magnetic surface. Here, we developed spin-selective charge transfer (SSCT)-based label-free surface-enhanced Raman scattering (SERS) achiral magnetic substrates for the enantioselective discrimination of chiral molecules without creating asymmetric chiral adsorption sites.

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Background: Adherence to recommended follow-up schedules for remote monitoring (RM) of patients with implantable cardioverter-defibrillators (ICDs) is inconsistent, which may influence clinical outcomes. Systematic organization through a "third-party" universal monitoring system (UMS) may be beneficial.

Objective: We aimed to evaluate the clinical impact of RM and any incremental benefit of UMS vs conventional RM.

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Flexible thermoelectric materials are usually fabricated by incorporating conducting or organic polymers; however, it remains a formidable task to achieve high thermoelectric properties comparable to those of their inorganic counterparts. Here, we present a high zT value of 1.29 ± 0.

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Objective: B-HOLISTIC was a real-world retrospective study of treatment patterns and clinical outcomes in Hodgkin lymphoma (HL) in regions outside Europe and North America. This subgroup analysis reports findings from Saudi Arabia, Türkiye, and South Africa.

Materials And Methods: Patients aged ≥18 years and diagnosed with stage IIB-IV classical HL receiving frontline chemotherapy (frontline cHL) and/or with relapsed/refractory HL (RRHL) from January 2010 to December 2013 were assessed.

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Apartheid had a devastating impact on medical education in South Africa. Until the development of the University of Natal Medical School in 1951, there were minimal opportunities for blacks (collectively Africans, Indians and so-called coloureds) to undertake undergraduate and postgraduate medical training in South Africa. At the height of apartheid (1968-1977), whites who had constituted 17% of the population, accounted for up to 87% of all medical graduates.

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In fuel cells and electrolyzers, suboptimal proton conductivity and its dramatic drop at low humidity remain major drawbacks in proton exchange membranes (PEMs), including current benchmark Nafion. Sustained through-plane (TP) alignment of nanochannels was proposed as a remedy but proved challenging. We report an anisotropic composite PEM, mimicking the water-conductive composite structure of bamboo that meets this challenge.

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Purpose Of Review: To survey recent progress in the application of implantable and wearable sensors to detection and management of cardiac arrhythmias.

Recent Findings: Sensor-enabled strategies are critical for the detection, prediction and management of arrhythmias. In the last several years, great innovation has occurred in the types of devices (implanted and wearable) that are available and the data they collect.

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The accessory anterolateral talar facet (AALTF) is an anatomical variation that broadens the apex of the lateral talar process. Studies have associated it with other tarsal coalitions as a cause of rigid painful flatfoot. However, a coalition of an AALTF has never been described before.

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Article Synopsis
  • Leadless left ventricular (LV) endocardial pacing is a new technology for cardiac resynchronization therapy (CRT) that aims to improve patient outcomes, but the factors affecting its effectiveness are not well understood.
  • This study analyzed data from the SOLVE-CRT trial to investigate how electrical latency at LV pacing sites (referred to as Q-LV) correlates with improved heart function measured as reduced left ventricular end-systolic volume (LVESV) over six months.
  • The findings revealed that higher Q-LV levels were linked to better heart function recovery, especially in patients with ischemic cardiomyopathy, implying that targeting high Q-LV areas for electrode placement might enhance the effectiveness of leadless CRT.
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  • α-NaMnO@NaMnO and KMnO@NaMnO nanocomposites were created using a solid-state reaction method, resulting in a distinct column-shaped structure observed through FESEM imaging.* -
  • FTIR analysis showed that the vibration frequencies changed with potassium loading, indicating alterations in the material's properties.* -
  • Electrochemical tests revealed high specific capacitance values of ∼361 F/g for α-NaMnO@NaMnO and ∼143 F/g for KMnO@NaMnO, along with excellent cycle stability and lower resistance, making them efficient options for supercapacitor use.*
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  • Cardiac contractility modulation (CCM) is an FDA-approved therapy for heart failure that uses electric stimulation to enhance heart muscle contractions.
  • CCM has been shown to improve various health metrics like quality of life, heart function, and reduce hospitalizations due to heart issues.
  • The review will cover how CCM works, who should use it, supporting evidence, and potential future uses of this technology.
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Nanoscale or microscale surface texturing is an effective technique to tailor the tribological properties between two surfaces that are rubbed against each other. In order to achieve the desired frictional properties by a patterned surface, one needs an in-depth understanding of the underlying mechanisms. Here, we demonstrate anisotropic stick-slip friction achieved via a nanotextured surface of tilted titania nanorods (TiNRs).

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Evaluating gynecological mass lesions and reviewing their morphological characteristics based on their imaging appearance on magnetic resonance imaging (MRI), and correlating the MRI findings with histopathological findings, was the central theme of our study. This observational cross-sectional study was conducted on 60 female patients with clinically suspected gynecological mass lesions upon physical examination and/or ultrasonography, referred for MRI at a tertiary care hospital over a 1-year period between June 2022 and July 2023. A broad spectrum of differential diagnoses of gynecological masses was observed.

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Article Synopsis
  • About 40% of heart failure patients eligible for cardiac resynchronization therapy (CRT) do not respond or cannot be treated, highlighting the need for alternative options.
  • The SOLVE-CRT study evaluated the safety and effectiveness of a new leadless left ventricular pacing system for high-risk patients or those who had unsuccessful CRT using conventional methods.
  • The study involved 183 participants, primarily older males, and was stopped early due to positive results showing improvements in safety and a decrease in heart chamber size.
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The COVID-19 pandemic came with many setbacks, be it to a country's economy or the global missions of organizations like WHO, UNICEF or GTFCC. One of the setbacks is the rise in cholera cases in developing countries due to the lack of cholera vaccination. This model suggested a solution by introducing another public intervention, such as adding Chlorine to water bodies and vaccination.

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Nanoplastics (NPs) generated from plastic debris weathering pose a significant threat to ecosystems. The ubiquity of plastics driven by their advantageous physical properties, necessitates the development of efficient degradation and removal methods. Polystyrene (PS), a common and hazardous aquatic NP is a long-chain hydrocarbon with alternating phenyl groups.

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Plant diseases pose a significant threat to agricultural productivity worldwide. Convolutional neural networks (CNNs) have achieved state-of-the-art performances on several plant disease detection tasks. However, the manual development of CNN models using an exhaustive approach is a resource-intensive task.

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There are numerous cases reported of the accessory muscles of the hand and wrist in surgical, cadaveric, and imaging-based studies. Anatomical muscle variations in the flexor compartment of the wrist and forearm can present as a pseudo mass or space-occupying lesion causing external compression on the traversing nerves. Guyon's canal is a compact space with a high potential for nerve entrapment.

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Aims: Significant changes in tricuspid regurgitation (TR) and mitral regurgitation (MR) post-cardiac implantable electronic devices (CIEDs) are increasingly recognized. However, uncertainty remains as to whether the risk of CIED-associated TR and MR differs with right ventricular pacing (RVP) via CIED with trans-tricuspid RV leads, compared with cardiac resynchronization therapy (CRT), conduction system pacing (CSP), and leadless pacing (LP). The study aims to synthesize extant data on risk and prognosis of significant post-CIED TR and MR across pacing strategies.

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