Environ Toxicol Pharmacol
March 2023
Tungsten is used in several applications and human exposure may occur. To assess its pulmonary toxicity, we exposed male mice to nose-only inhalation of tungsten particles at 9, 23 or 132 mg/m (Low, Mid and High exposure) (45 min/day, 5 days/week for 2 weeks). Increased genotoxicity (assessed by comet assay) was seen in bronchoalveolar (BAL) fluid cells at Low and High exposure.
View Article and Find Full Text PDFMolybdenum disulphide (MoS) is a constituent of many products. To protect humans, it is important to know at what air concentrations it becomes toxic. For this, we tested MoS particles by nose-only inhalation in mice.
View Article and Find Full Text PDFThe inclusion of nanoparticles can increase the quality of certain products. One application is the inclusion of Zinc oxide (ZnO) nanoparticles in a glass coating matrix to produce a UV-absorbing coating for glass sheets. Yet, the question is whether the inclusion of ZnO in the matrix induces toxicity at low exposure levels.
View Article and Find Full Text PDFThe rate of translocation of ingested nanoparticles (NPs) and how the uptake is affected by a food matrix are key aspects of health risk assessment. In this study, female Sprague Dawley rats (N = 4/group) received 0, 1.4, or 13 mg of cerium oxide (CeO NM-212) NPs/rat/day by gavage or in a chocolate spread snack 5 days/week for 1 or 2 weeks followed by 2 weeks of recovery.
View Article and Find Full Text PDFBackground: The problems of burnout and the moral and ethical distress resulting from various kinds of conflict have been raised in the veterinary profession. However, their sources and inter-relationships have not been thoroughly recognized mainly due to the multidimensional nature of human interactions related to animal breeding, farming, welfare, prophylaxis and therapy. For the first time in Poland, an analysis of conflict and conflict-causing factors in veterinary practice has been conducted with the participation of veterinarians of various specialties and the owners of different animal species.
View Article and Find Full Text PDFSurface modification by different quaternary ammonium compounds (QAC) makes nanoclays more compatible with various polymeric matrices, thereby expanding their potential applications. The growing industrial use of nanoclays could potentially pose a health risk for workers. Here, we assessed how surface modification of nanoclays modulates their pulmonary toxicity.
View Article and Find Full Text PDFIntroduction: The clinical symptoms of portosystemic shunts (PSSs) and hepatic microvascular dysplasia (HMD) - portal vein hypoplasia (PVH) in dogs are similar. PSSs are abnormal vascular connections between the portal vein system and systemic veins. HMD is a very rare developmental vascular anomaly, recognisable during histopathological examination.
View Article and Find Full Text PDFThe aim of this study is to depict the current and past research directions in Polish pathology at the turn of the centuries. The analysis was based on the abstracts of the congresses of the Polish Society of Pathologists organized in 1992-2016 and concerned 1,824 presentations. It has been proven that oncology (1,090 presentations, 59.
View Article and Find Full Text PDFMulti-walled carbon nanotubes (MWCNT) are widely used nanomaterials that cause pulmonary toxicity upon inhalation. The physicochemical properties of MWCNT vary greatly, which makes general safety evaluation challenging to conduct. Identification of the toxicity-inducing physicochemical properties of MWCNT is therefore of great importance.
View Article and Find Full Text PDFThe objective of this paper is to depict the current research directions in veterinary pathology in Europe. The analysis was carried out based on the abstracts and agendas of the annual European Society of Veterinary Pathology (ESVP) congresses organised together with the European College of Veterinary Pathologists (ECVP) in 2010-2016. In total, 1444 presentations were evaluated, including 41 plenary lectures, 319 short oral presentations, and 1081 posters, and in 2016 also three science slams.
View Article and Find Full Text PDFWe investigated environmental impacts on rainbow trout (Oncorhynchus mykiss) reared at fish farms with either extensive technology, in a flow-through system (FTS, n = 3), or intensive technology, in a recirculating aquaculture system (RAS, n = 3). All fish were fed the same rations. Fish were caught in spring and autumn (body mass, 501-750 g) from these six farms.
View Article and Find Full Text PDF[b]Abstract [/b] Dogs serve as the vectors of serious zoonotic parasitic diseases. In the month of May 2012 - 2014, 339 dog faeces samples from seven public sites in Chełmno, a town in northern Poland, were collected and examined to determine the gastrointestinal parasite fauna of dogs. Each faecal sample was dissected with a needle, checked for tapeworm segments and examined for parasite eggs and oocysts using the flotation and decantation method and a modified Baermann technique.
View Article and Find Full Text PDFBackground: The toxicity of dusts from mechanical abrasion of multi-walled carbon nanotube (CNT) epoxy nanocomposites is unknown. We compared the toxic effects of dusts generated by sanding of epoxy composites with and without CNT. The used CNT type was included for comparison.
View Article and Find Full Text PDFInhalation is the main pathway of ZnO exposure in the occupational environment but only few studies have addressed toxic effects after pulmonary exposure to ZnO nanoparticles (NP). Here we present results from three studies of pulmonary exposure and toxicity of ZnO NP in mice. The studies were prematurely terminated because interim results unexpectedly showed severe pulmonary toxicity.
View Article and Find Full Text PDFAdverse lung effects following pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) are well documented in rodents. However, systemic effects are less understood. Epidemiological studies have shown increased cardiovascular disease risk after pulmonary exposure to airborne particles, which has led to concerns that inhalation exposure to MWCNTs might pose similar risks.
View Article and Find Full Text PDFBackground: Non-steroidal anti-inflammatory drugs (NSAIDs) may cause gastrointestinal damage in dogs.
Hypothesis/objectives: To determine the extent to which lansoprazole, liquorice extract, and a herbal solution exhibit protective effects on colonic mucosa when administered to dogs concurrently with the NSAIDs carprofen or robenacoxib.
Animals And Methods: Thirty-five healthy beagle dogs (15 male and 20 female) aged 13-14 weeks and weighing 4.
We studied the effects of preconceptional exposure to multiwalled carbon nanotubes (MWCNTs): mature, female C57BL/6J mice were intratracheally instilled with 67μg NM-400 MWCNT, and the following day co-housed with mature males, in breeding pairs. Time to delivery of the first litter, litter parameters, maternal inflammation and histopathology of lung and liver were recorded. In male offspring, locomotor activity, startle response, and daily sperm production (DSP) were assessed.
View Article and Find Full Text PDFConcentrations of cadmium and lead were measured in liver and kidneys of Mallard (n=60) and Coot (n=50). Free living birds were collected by hunters in years 2006-2008 in the area of fishponds near Zator in southern Poland. Age group was determined according to the appearance of the plumage (Mallards) and iris color (Coot).
View Article and Find Full Text PDFBackground: Little is known of how the toxicity of nanoparticles is affected by the incorporation in complex matrices. We compared the toxic effects of the titanium dioxide nanoparticle UV-Titan L181 (NanoTiO2), pure or embedded in a paint matrix. We also compared the effects of the same paint with and without NanoTiO2.
View Article and Find Full Text PDFThis paper presents the main trends in the activity of veterinary pathologists in the context of their oral presentations, short speeches and posters during annual congresses of the European Society of Veterinary Pathology (ESVP) in the years 1997-2009. During the thirteen analyzed congresses, 2668 presentations were prepared, including 72 plenary lectures, 946 short oral presentations and 1489 posters. Based on the analysis, organ pathology (779 presentations) was the most popular branch of pathology.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
March 2011
Unlabelled: BACKGROUND AIM AND SCOPE: The objective of the study was to determine the effects of ca. 35 years of pesticide contamination (pesticide dump-PD) of Lake Szeląg Wielki (located in the north-eastern Poland) on changes in the microbial communities of aquatic ecosystems. In the years 2008-2009, analyses were carried out for seasonal changes in the quantity and composition of bacterioplankton in the lake examined, which is of high significance to the tourism and fishing industries and is located in the vicinity of an area subjected to reclamation after a pesticide dump.
View Article and Find Full Text PDFLateral electrical surface stimulation is one of methods used in the therapy of the progressive form of idiopathic scoliosis (IS) in children and youth. However, there are data suggesting that this method may lead to serious adverse side effects, when used for a too long period of time per day. To clarify this issue, the present study was aimed at disclosing possible changes in the ultrastructural appearance of rabbit supraspinal muscles undergoing long-term stimulation (9 h per day, 3 months), an animal model successfully used to mimic the situation in humans.
View Article and Find Full Text PDFThe objective of this study was to identify the histopathological features of paravertebral muscles after long-term Lateral Electrical Surface Stimulation (LESS). LESS has been applied for the treatment of idiopathic scoliosis in children and adolescents. Former studies reported the negative effect on the mental state of treated patients, as well as functional disturbances of organs, endocrine glands, and muscle metabolism.
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