Status of sperm morphology assessment: an evaluation of methodology and clinical value.

Objective: To characterize methodological changes in sperm morphology assessment and to correlate sperm morphology with clinical outcome.

Design: In this observational study, sperm morphology profiles of patients were analyzed. The percentages of morphologically normal spermatozoa were evaluated with respect to changes in morphology assessment criteria; male aging; and prognostic value for outcomes after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).