Correlation between vascular endothelial growth factor-A expression and tumor location and invasion in patients with colorectal cancer.

Background: Vascular endothelial growth factor-A (VEGF-A) has been observed as the predominant angiogenic factor in colorectal cancer (CRC) and the assessment of microvessel density (MVD) has been used to quantify tumor neoangiogenesis. This study aimed to determine clinicopathological and prognostic significance of both angiogenic markers in the local CRC patients.

Methods: We analyzed tissue samples obtained from 81 cases with CRC.