Publications by authors named "Joyce de Paula Souza"
Increased activity of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome-IL-1β pathway is observed in obesity and contributes to the development of type 2 diabetes and its complications. In this review, we describe the pathological activation of IL-1β by metabolic stress, ageing and the microbiome and present data on the role of IL-1β in metabolism. We explore the physiological role of the IL-1β pathway in insulin secretion and the relationship between circulating levels of IL-1β and the development of diabetes and associated diseases.
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- Postprandial IL-1β levels increase primarily in white adipose tissue (WAT), but its effects on metabolism were previously unclear.
- Deleting IL-1 receptor 1 (IL1R1) specifically in fat cells doesn't impact metabolism, while its absence throughout the body leads to reduced body weight and WAT mass in mice.
- IL-1β encourages fat cell development (adipogenesis) in early-stage stem cells by activating specific transcription factors, suggesting that short-term IL-1β spikes may help WAT adapt, while constant high levels in obesity could hinder this process.