Publications by authors named "Joyce P Pasion"
Cancer cells adapt their metabolic activities to support growth and proliferation. However, increased activity of metabolic enzymes is not usually considered an initiating event in the malignant process. Here, we investigate the possible role of the enzyme serine hydroxymethyltransferase-2 (SHMT2) in lymphoma initiation.
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- Follicular lymphoma (FL) is an incurable B cell lymphoma characterized by specific genetic abnormalities, including the t(14;18) translocation and losses of chromosome 6q.
- Researchers identified a gene linked to the 6q deletion that plays a role in tumor suppression and is affected by a lymphoma-specific mutation, disrupting p53's regulation of mTORC1, which is crucial for mRNA translation under stress.
- The effectiveness of EZH2 inhibition in treating lymphoma relies on the protein SESTRIN1, which impacts mTORC1 activity; patients with mutations in SESTRIN1 may respond better to mTOR inhibitors like RapaLink-1.