Publications by authors named "Joyce L Y Tang"
Article Synopsis
- The study investigates a new cancer treatment system called Chit-IOCO-MTX-Cy5, which combines chitosan nanocomposites with cerium oxide and iron oxide nanoparticles, along with methotrexate and a dye for imaging.
- The system acts as both an anti-cancer agent and enhances MRI imaging, showing high effectiveness with better results than currently approved imaging agents.
- It significantly reduces tumor growth with no regrowth after treatment, while showing good safety in mice, indicating its potential as an effective cancer theranostic tool.
Nanoceria or cerium oxide nanoparticles characterised by the co-existing of Ce and Ce that allows self-regenerative, redox-responsive dual-catalytic activities, have attracted interest as an innovative approach to treating cancer. Depending on surface characteristics and immediate environment, nanoceria exerts either anti- or pro-oxidative effects which regulate reactive oxygen species (ROS) levels in biological systems. Nanoceria mimics ROS-related enzymes that protect normal cells at physiological pH from oxidative stress and induce ROS production in the slightly acidic tumour microenvironment to trigger cancer cell death.
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