Publications by authors named "Joyce J Calixto"
J Biomol Screen
June 2002
Article Synopsis
- The study investigates how the CB(1) receptor's signaling varies between its natural G(i/o) coupling and an engineered G(alpha 16) system.
- Competition binding studies showed similar ligand affinities for both hCB(1) and the hCB(1)-G(alpha 16) fusion protein.
- While the hCB(1) receptor couples to G(i/o) for certain responses, both coupling mechanisms lead to similar increases in intracellular calcium concentration, indicating functionality remains largely unchanged.
