Publications by authors named "Joyce Dickey"
Article Synopsis
- - PAR4 is a potential target for developing new antithrombotic drugs that could reduce bleeding risks compared to current treatments.
- - Researchers discovered a promising compound through high-throughput screening (HTS) and improved it using structural optimizations, resulting in a new series that effectively blocks PAR4.
- - The leading compound showed exceptional potency (2 nM IC) against PAR4 and significant selectivity, making it highly effective in preventing thrombosis with minimal bleeding side effects in monkey models.
Among the several goals of a high-throughput screening campaign is the identification of as many active chemotypes as possible for further evaluation. Often, however, the number of concentration response curves (e.g.
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