Publications by authors named "Joyce Blokker"
In Rspondin-based 3D cultures, Lgr5 stem cells from multiple organs form ever-expanding epithelial organoids that retain their tissue identity. We report the establishment of tumor organoid cultures from 20 consecutive colorectal carcinoma (CRC) patients. For most, organoids were also generated from adjacent normal tissue.
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- Somatic mutations in a cell's genome accumulate throughout an organism's life and can reveal the developmental history and number of cell divisions that occurred.
- The study analyzed clonal lines from various healthy mouse tissues, using somatic base substitutions to reconstruct early cell divisions and understand the contributions of embryonic cells to adult tissues.
- Findings showed variations in mutation types and rates across different tissues, suggesting these differences are linked to the number of cell divisions and diverse mutational processes, potentially aiding insights into human cell development and mutations.
Ultrastructural localization and expression of TRPM1 in the human retina.
Invest Ophthalmol Vis Sci
October 2011
Purpose: Transient receptor potential subfamily melastatin (TRPM)1 cation channels of retinal ON-bipolar cells are modulated via a mGluR6 (GMR6) signaling cascade. While light-microscopy shows these channels are located on the tips of ON-bipolar cells dendrites, near rod and cone synaptic ribbons, TRPM1 localization at the electron-microscope level is currently not described. The authors report here the ultrastructural localization of TRPM1 in the human retina.
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