Publications by authors named "Joyanna G Hansen"
Objective: Increased infant birth weight and adiposity are associated with an altered risk of adult chronic diseases. The objective was to investigate the association between maternal dietary fat intake during pregnancy and newborn adiposity.
Study Design: The study included 79 singleton pregnancies.
Background: Low circulating 25-hydroxyvitamin D [25(OH)D] is prevalent in African Americans, but predictors of vitamin D status are understudied compared to Caucasian populations.
Objective: We investigated whether certain environmental and genetic factors are predictors of circulating 25(OH)D in 989 elderly African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study.
Methods: Regression analysis estimated the cross-sectional association of nongenetic (environmental) factors with 25(OH)D.
Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.
Methods: We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci.
Article Synopsis
- Vitamin D has potential links to lung health, but the mechanisms behind these associations are unclear; this study aims to investigate those mechanisms through gene expression and population-based analyses.
- The research found 13 genes that showed significant expression changes related to serum levels of Vitamin D, with SGPP2 emerging as a key gene linked to lung function in different populations.
- The results highlight SGPP2 as a new vitamin D-responsive gene potentially influencing lung health, suggesting that further studies are needed to validate these findings.
Antioxidant nutritional status is hypothesized to influence chronic obstructive pulmonary disease (COPD) susceptibility and progression. Although past studies relate antioxidants to gene expression, there are no data in patients with COPD. This study investigated the hypothesis that antioxidant status is compromised in patients with COPD, and antioxidant-responsive genes differentially express in a similar pattern.
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