Publications by authors named "Joy Zhuo"
Article Synopsis
- The SiaA protein in Streptococcus pyogenes is involved in heme uptake and was studied through mutations to understand how these changes affect heme binding.
- pH titrations revealed that mutations led to similar pKa values compared to the wild-type, but resonant Raman spectra indicated a different heme environment in the mutants.
- The study suggests that the unfolding of SiaA is influenced by the interaction strength of its amino acid residues with heme, proposing a mechanism where minor structural changes allow for heme release while maintaining overall protein stability for ongoing heme trafficking.
