Publications by authors named "Joy Yu Zuchero"
Article Synopsis
- Genetic mutations related to familial Alzheimer's disease have been researched for decades, but effective treatments are still lacking, leading to the development of new, more accurate mouse models using knock-in techniques to study the disease.
- The study engineered a novel App knock-in mouse model to analyze the effects of specific Alzheimer's mutations, investigating various factors such as amyloid-β pathology, neurodegeneration, and microglial responses through advanced imaging and analysis methods.
- Findings revealed significant changes in lipids and metabolites as well as a heightened microglial response related to Alzheimer's pathology, enhancing the understanding of the disease and its effects on the brain's immune response.
Treatment of diseases of the central nervous system by monoclonal antibodies may be limited by the restricted uptake of antibodies across the blood-brain barrier (BBB). An antibody targeting transferrin receptor (TfR) has been shown to take advantage of the receptor-mediated transcytosis properties of TfR in order to cross the BBB in mice, with the uptake in the brain being dependent on the affinity to TfR. In the bispecific format with arms targeting both TfR and β-secretase 1 (BACE1), altering the affinity to TfR has been shown to impact systemic exposure and safety profiles.
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