A Concise Review on Different Aspects of Influences of Coronavirus Disease 2019 on Liver and Metabolic Changes.

Purpose: Coronavirus disease 2019 (COVID-19) is a viral disease, causing a deadly situation around the world. Significant cases need hospitalization and intensive care. Obese, diabetic, and immunosuppressed people have poor prognosis.

Spinster Homologue 2 Expression Correlates With Improved Patient Survival in Hepatocellular Carcinoma Despite Association With Lymph-Angiogenesis.

Background: Spinster homologue 2 (SPNS2) is a transporter of sphingosine-1-phosphate (S1P), a bioactive lipid linked to cancer progression. We studied the link between gene expression, tumor aggressiveness, and outcomes in patients with hepatocellular carcinoma (HCC).

Methods: Gene expression in patients with HCC was analyzed from the Cancer Genome Atlas (TCGA) (n = 350) and GSE76427 (n = 115) as a validation cohort, as well as liver tissue cohort GSE6764 (n = 75).

Surgeon-Dependent Variability in Cost of Gastrointestinal Operations in a Single Cancer Center.

Introduction: Cancer operations are increasingly utilizing specialized equipment and technology. Related costs are often not known to the responsible surgeon. We seek to evaluate cost aspects of care episodes attributable to the surgeon's management decisions.

Perioperative Chemotherapy is Associated with Superior Overall Survival in Patients with Synchronous Colorectal Liver Metastases.

Background: The sequence of localized and systemic treatment for colorectal liver metastases (CRLM) remains debated. Our objective is to analyze the effect of treatment sequence on overall survival (OS) in patients with CRLM using a large cancer database.

Patients And Methods: The national cancer database (NCDB) was utilized to identify patients with stage IV colorectal cancer (CRC) diagnosed between 2004 and 2016.

Bilateral adrenal hemorrhage after pancreaticoduodenectomy.

The incidence of bilateral adrenal hemorrhage (BAH) in the postoperative setting is rare, but potentially life threatening. A literature review of postoperative BAH reveals that there is limited data on BAH following abdominal surgery. We present a case of BAH following pancreaticoduodenectomy, which has not been previously documented in the literature.

Fluctuations in Gut Microbiome Composition During Immune Checkpoint Inhibitor Therapy.

Background: Immune checkpoint inhibitors (ICIs) such as programmed cell death protein-1 (PD-1) inhibitors or PD-1 ligand-1 (PD-L1) inhibitors have led to remarkable improvement in outcomes of non-small cell lung cancer (NSCLC). Unfortunately, the significant benefits of ICI therapy are frequently limited by resistance to treatment and adverse effects, and the predictive value of pre-treatment tumor tissue PD-L1 expression is limited. Development of less invasive biomarkers that could identify responders and non-responders in early on-treatment could markedly improve the treatment regimen.

Low incisional hernia incidence using a large-bite, low-tension technique for celiotomy closure.

Background: Incisional herniae (IH) are reported in 5->20 % of patients undergoing open celiotomy, and can be linked to closure technique. The STITCH randomized trial favors a small bite technique for midline celiotomy closure with a 1-year IH rate of 13 % over larger bites (23 %).

Methods: A continuous musculofascial mass closure with absorbable looped #1 PDS suture with 2-cm bite size was used for all open celiotomies.

Predictive and Prognostic Implications of Circulating CX3CR1 CD8 T Cells in Non-Small Cell Lung Cancer Patients Treated with Chemo-Immunotherapy.

Unlabelled: Lack of reliable predictive biomarkers is a major limitation of combination therapy with chemotherapy and anti-programmed cell death protein 1/programmed death-ligand 1 (anti-PD-1/PD-L1) therapy (chemo-immunotherapy). We previously observed that the increase of peripheral blood CD8 T cells expressing CX3CR1, a marker of differentiation, correlates with response to anti-PD-1 therapy; however, the predictive and prognostic value of T-cell CX3CR1 expression during chemo-immunotherapy is unknown. Here, we evaluated the utility of circulating CX3CR1CD8 T cells as a predictive correlate of response to chemo-immunotherapy in patients with non-small cell lung cancer (NSCLC).

"Evaluation of physico-mechanical properties of naturally dyed betel-nut leaf plate (BLPF) - Banana blended fabric".

Betel-nut leaf plate fiber (BLPF) is a lingo-cellulosic natural fiber that can be used to make eco-friendly and biodegradable blended or hybrid fabric with Banana fiber. In the world of organic textiles, naturally dyed BLPF-Banana fiber can be used for wearable products and satisfy health and hygiene issues. BLPF and Banana fiber can be good natural fibers for hybrid fabrics despite being considered waste materials.

A State-of-the-Art Systemic Review on Selenium Nanoparticles: Mechanisms and Factors Influencing Biogenesis and Its Potential Applications.

Selenium is a trace element required for the active function of numerous enzymes and various physiological processes. In recent years, selenium nanoparticles draw the attention of scientists and researchers because of its multifaceted uses. The process involved in chemically synthesized SeNPs has been found to be hazardous in nature, which has paved the way for safe and ecofriendly SeNPs to be developed in order to achieve sustainability.

Conjugated Bile Acids Accelerate Progression of Pancreatic Cancer Metastasis via S1PR2 Signaling in Cholestasis.

Background: Pancreatic cancer (PC) has an extremely high mortality rate, where obstructive jaundice due to cholestasis is a classic symptom. Conjugated bile acids (CBAs) such as taurocholic acid (TCA) have been reported to activate both the ERK1/2 and AKT signaling pathways via S1P receptor 2 (S1PR2) and promote growth of cholangiocarcinoma. Thus, we hypothesize that CBAs, which accumulate in cholestasis, accelerate PC progression via S1PR2.

Higher intra-tumoral expression of pro-coagulation genes is a predictor of angiogenesis, epithelial mesenchymal transition and worse patient survival in gastric cancer.

Coagulation regulates angiogenesis in cancer, and is associated with tumor development and metastasis. To date, there have been no studies quantifying the state of intra-tumoral coagulation. We measured intra-tumoral coagulation gene expression using the "Hallmark-COAGULATION" gene set in the MSigDB, performing gene set variation analysis and then assigning a "coagulation score" to quantify gene expression.

Benzalkonium chloride, a common ophthalmic preservative, compromises rat corneal cold sensitive nerve activity.

Purpose: Corneal nerves comprise the densest sensory network in the body. Dysfunction of the corneal cold sensitive neurons (CSN) is implicated in ophthalmic disorders, including Dry Eye Disease, the most common ocular surface disorder. The preservative Benzalkonium chloride (BAK) and the mydriatic agent Phenylephrine hydrochloride (PHE) are considered to be inactive at the level of the CSNs.

I-Health: SDN-Based Fog Architecture for IIoT Applications in Healthcare.

The Industrial Internet of Things (IIoT) has been introduced in an era of increasingly broad potentials in the medical industry. In recent years, IIoT-based healthcare applications have grown in popularity, with the majority of them relying on Wireless Body Area Network (WBAN) for flexibility. There have been a few recent works that have investigated SDN-based fog architecture for constructing smart healthcare systems.

VEGF receptor heterodimers and homodimers are differentially expressed in neuronal and endothelial cell types.

Purpose: We have previously reported that VEGF-B is more potent than VEGF-A in mediating corneal nerve growth in vitro and in vivo, and this stimulation of nerve growth appears to be different from stimulation of angiogenesis by these same ligands, at least in part due to differences in VEGF receptor activation. VEGF signaling may be modulated by a number of factors including receptor number or the formation of receptor hetero- vs. homodimers.

Antiviral potential of nanoparticles for the treatment of Coronavirus infections.

Background: On 31st December 2019 in Wuhan, China, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was acknowledged. This virus spread quickly throughout the world causing a global pandemic. The World Health Organization declared COVID-19 a pandemic disease on 11th March 2020.

Tuberculosis and COVID-19: A combined global threat to human civilization.

A new era has begun with the discovery of SARS-CoV-2 in a seafood market in Wuhan, China. The SARS-CoV-2 outbreak has wreaked havoc on health systems and generated worldwide attention. The world's attention was diverted from the treatment of the leading chronic infectious illness, .

Mucormycosis: A new threat to Coronavirus disease 2019 with special emphasis on India.

The main reason for the growth of mucormycosis in people with Coronavirus disease-2019 (COVID-19) is mainly produced by spp. The infective mechanisms and issues recognized in spp. are the cell wall, germination proteins, and enzymes assisted to iron sequestration, CotH protein, and positive regulation of the GRP78 cell receptor.