Publications by authors named "Joy S Woodward"
Article Synopsis
- Female mammals have two X chromosomes, but to keep things balanced with males (who have one), one X usually gets inactive.
- In early mouse embryos and stem cells, both X chromosomes stay active for a while before one gets turned off, leading to a mix of cells with different active X chromosomes.
- Rhesus monkey stem cells show a similar pattern, but their early embryos keep both Xs active for longer and show different ways of regulating these genes compared to mice.
Optimal function of the serotonin system is essential for mental health and its role in psychopathologies is undisputed. Enhancing the ability to study primate serotonin neurons in culture would facilitate understanding of intracellular signaling pathways that mediate the action of drugs and other epigenetic or developmental factors impacting human mental health. We were the first group to report differentiation of the non-human primate rhesus monkey embryonic stem cell (ESC) line 366.
View Article and Find Full Text PDF