Publications by authors named "Joy Paramor"
One strategy to prevent islet rejection is to create a favorable immune-protective local environment at the transplant site. Herein, we utilize localized cyclosporine A (CsA) delivery to islet grafts via poly(lactic-co-glycolic acid) (PLGA) microparticles to attenuate allograft rejection. CsA-eluting PLGA microparticles were prepared using a single emulsion (oil-in-water) solvent evaporation technique.
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- Beta cell replacement therapies show promise for improving blood sugar control in type 1 diabetes, but long-term immune suppression limits their effectiveness compared to insulin.
- Researchers studied a coating made from poly(N-vinylpyrrolidone) and tannic acid (PVPON/TA) to protect transplanted islets from the immune system while maintaining their function.
- Results indicated that both coated and non-coated islets performed similarly in lab tests, and the PVPON/TA-coating improved transplant outcomes by reducing inflammation and delaying rejection in mice.