Publications by authors named "Joy Omini"
This review discusses the intriguing yet controversial concept of metabolons, focusing on the malate dehydrogenase-citrate synthase (MDH-CISY) metabolon as a model. Metabolons are multienzyme complexes composed of enzymes that catalyze sequential reactions in metabolic pathways. Metabolons have been proposed to enhance metabolic pathway efficiency by facilitating substrate channeling.
View Article and Find Full Text PDFMitochondrial cytochrome c maturation (CCM) requires heme attachment via distinct pathways termed systems I and III. The mosaic distribution of these systems in Archaeplastida raises questions about the genetic mechanisms and evolutionary forces promoting repeated evolution. Here, we show a recurrent shift from ancestral system I to the eukaryotic-specific holocytochrome c synthase (HCCS) of system III in 11 archaeplastid lineages.
View Article and Find Full Text PDFArticle Synopsis
- The mitochondrial malate dehydrogenase-citrate synthase (MDH-CS) multi-enzyme complex is crucial for the Krebs cycle, enabling efficient enzymatic reactions without losing intermediates.
- The study found that substrates like NAD and acetyl-CoA promote the formation of this complex, whereas products like NADH and citrate weaken it.
- Additionally, factors such as oxaloacetate (only with acetyl-CoA), ATP, and low pH contribute to the stability and interaction of the MDH-CS complex, indicating its role in regulating the Krebs cycle based on metabolic needs.