Publications by authors named "Joy G Cagmat"
Aims: Pathological dental root resorption and alveolar bone loss are often detected only after irreversible damage. Biomarkers in the gingival crevicular fluid or saliva could provide a means for early detection; however, such biomarkers have proven elusive. We hypothesize that a multiomic approach might yield reliable diagnostic signatures for root resorption and alveolar bone loss.
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- - The current targeted metabolomic workflows have limitations that can result in loss of key metabolic process information due to the sequential isolation of analytes, leading to variability and reduced data points in mass spectrometry analysis.
- - Using a wide-isolation window during fragmentation can enhance consistency in quantitation while maintaining faster scan rates, which helps in accurately representing chromatographic peaks for better analysis.
- - This study applied a new method combining wide-isolation quantitative strategies and qualitative metabolomics to analyze tryptophan degradation in mouse serum, revealing important insights into the kynurenine pathway and its metabolites.