Publications by authors named "Joy Folahan"
Endothelial injury can be the cause and consequence of severe inflammation and injury. Synthetic somatostatin analogs-which suppress Growth Hormone-are clinically-approved drugs associated with anti-inflammatory activities. In the present study, we suggest that the protective activities of Octreotide in human and bovine endothelial cells are mitigated by Ceapin-A7, which is an activating transcription factor 6 inhibitor.
View Article and Find Full Text PDFEndothelial Unfolded Protein Response-Mediated Cytoskeletal Effects.
Cell Biochem Funct
December 2024
The endothelial semipermeable monolayers ensure tissue homeostasis, are subjected to a plethora of stimuli, and their function depends on cytoskeletal integrity and remodeling. The permeability of those membranes can fluctuate to maintain organ homeostasis. In cases of severe injury, inflammation or disease, barrier hyperpermeability can cause irreparable damage of endothelium-dependent issues, and eventually death.
View Article and Find Full Text PDFOxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo.
Lipids Health Dis
July 2023
Background: Thermoxidation of edible oil through deep fat frying results in the generation of several oxidized products that promote lipid peroxidation and ROS production when eaten. Consumption of thermoxidized oil in post-menopausal conditions where the estrogen level is low contributes to cardiovascular disease. This study evaluates the role of estradiol and antihyperlipidemic agents (AHD) in restoring the vascular health of ovariectomized (OVX) rats fed with thermoxidized palm oil (TPO) and thermoxidized soya oil (TSO) diets.
View Article and Find Full Text PDFArticle Synopsis
- The PI3K-Akt-mTOR signaling pathway is linked to various inflammatory skin conditions, which can lead to ineffective treatments for diseases like acne and psoriasis.
- Understanding how this pathway operates has spurred the creation of new therapeutic strategies, but more research is needed to fully grasp its regulatory functions.
- Some natural and synthetic compounds show promise in inhibiting this pathway, highlighting their potential for treating persistent skin inflammatory disorders.
The Genus Vahl.: Ethnobotany, Phytochemistry and Biological Activities.
Pharmaceuticals (Basel)
May 2023
Article Synopsis
- Vahl. species from the Burseraceae family are widely utilized in traditional medicine for treating various ailments like malaria, wounds, and infections.
- A systematic review highlighted their ethnobotanical uses, phytochemical profiles, and pharmacological benefits, revealing potential in areas such as anti-cancer and anti-inflammatory treatments.
- Despite promising findings, many therapeutic aspects of these plants remain under-researched, indicating a need for more rigorous scientific investigation to fully understand and exploit their medicinal properties.
Phytomedicines reportedly rich in cystine knot peptides (Knottins) are found in several global diets, food/herbal supplements and functional foods. However, their knottin peptide content has largely been unexplored, notably for their emerging dual potentials at both the food and medicine space. The nutritional roles, biological targets and mechanism(s) of activity of these knotted peptides are largely unknown.
View Article and Find Full Text PDFObjective: To evaluate the effect of the chronic use of combined oral contraceptives (COCs: ethinyl estradiol and levonorgestrel) on the indices of metabolic syndrome in adult female Wistar rats and possible therapeutic management.
Materials And Methods: 64 female Wistar rats received either distilled water, norethindrone (NOR), COC, intranasal insulin (INI), metformin (MET), saxagliptin (SAX), INI+MET, and INI+SAX. After 8 weeks of exposure to COC, the animals were sorted into the therapeutic groups.