Publications by authors named "Joy E Duer"
Article Synopsis
- Recurrent cancer cells are a major cause of death in breast cancer, especially in patients with high Her2 expression.
- This study investigates the metabolic changes in breast tumors as they transition through regression, dormancy, and recurrence, using imaging techniques to track energy production shifts.
- Fast-recurrence tumors change their energy source from glucose to fatty acids, and treatment with a fatty acid inhibitor can enhance glucose uptake and prolong survival, highlighting the importance of timing for effective therapy.
Targeting a tumor's metabolic dependencies is a clinically actionable therapeutic approach; however, identifying subtypes of tumors likely to respond remains difficult. The use of lipids as a nutrient source is of particular importance, especially in breast cancer. Imaging techniques offer the opportunity to quantify nutrient use in preclinical tumor models to guide development of new drugs that restrict uptake or utilization of these nutrients.
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