Effects of megestrol acetate on weight gain, body composition, and pulmonary function in patients with cystic fibrosis.

Objectives: Malnutrition is a negative prognostic indicator in patients with cystic fibrosis (CF) and may accentuate pulmonary decline. We tested whether megestrol acetate would have beneficial effects on growth in patients with CF and pancreatic insufficiency.

Study Design: We performed a randomized, double-blind, placebo controlled study.