Publications by authors named "Jovian Tsang"
Article Synopsis
- The prognosis for patients with advanced bone and soft-tissue sarcoma remains poor, showing the need for innovative treatment options like immunotherapy.
- A study compared four oncolytic viral platforms (Reovirus, Vaccinia virus, Herpes-simplex virus, and Rhabdovirus) and found that Rhabdovirus MG1 was the most effective at infecting and killing sarcoma cells.
- MG1 not only led to significant tumor cures in mouse models but also triggered a memory immune response, suggesting its potential as a standalone treatment or part of a combination therapy for sarcoma.
Oncolytic viruses designed to attack malignant cells can in addition infect and destroy tumor vascular endothelial cells. We show here that this expanded tropism of oncolytic vaccinia virus to the endothelial compartment is a consequence of VEGF-mediated suppression of the intrinsic antiviral response. VEGF/VEGFR2 signaling through Erk1/2 and Stat3 leads to upregulation, nuclear localization, and activation of the transcription repressor PRD1-BF1/Blimp1.
View Article and Find Full Text PDFHematological malignancies are treated with intensive high-dose chemotherapy, with or without radiation. This is followed by hematopoietic stem cell (HSC) transplantation (HSCT) to rescue or reconstitute hematopoiesis damaged by the anticancer therapy. Autologous HSC grafts may contain cancer cells and purging could further improve treatment outcomes.
View Article and Find Full Text PDFPurpose: Acute lymphoblastic leukemia (ALL) remains incurable in most adults. It has been difficult to provide effective immunotherapy to improve outcomes for the majority of patients. Rhabdoviruses induce strong antiviral immune responses.
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